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Literature DB >> 1240047

In vitro culture of functional human thymic epithelium.

Abstract

Cultures of pure epithelial cells have been obtained from human thymus. Incubation of spleen cells from adult thymectomized mice on these cultures rendered RFC sensitive to inhibition by anti-theta serum, whereas no effect was obtained with fibroblasts or spleen cell cultures. The fact that theta conversion was obtained when spleen cells were incubated in the thymic culture placed within a Millipore chamber indicates that theta conversion was due to the effect of a humoral factor.

Entities: Species

Mesh：

Substances：
Immune Sera

Year: 1975 PMID： 1240047 PMCID： PMC1538087

Source DB: PubMed Journal: Clin Exp Immunol ISSN： 0009-9104 Impact factor: 4.330

14 in total

1. Thymus reticulum cell cultures confer T cell properties on spleen cells from thymus-deprived animals.

Authors: H Wekerle; I R Cohen; M Feldman
Journal: Eur J Immunol Date: 1973-12 Impact factor: 5.532

2. Appearance of T-cell markers in bone marrow rosette-forming cells after incubation with thymosin, a thymic hormone.

Authors: J F Bach; M Dardenne; A L Goldstein; A Guha; A White
Journal: Proc Natl Acad Sci U S A Date: 1971-11 Impact factor: 11.205

3. Studies on thymus products. 3. Epithelial origin of the serum thymic factor.

Authors: M Dardenne; M Papiernik; J F Bach; O Stutman
Journal: Immunology Date: 1974-08 Impact factor: 7.397

4. In-vitro demonstration of thymic hormone in the mouse by conversion of precursor cells into lymphocytes.

Authors: K Komuro; E A Boyse
Journal: Lancet Date: 1973-04-07 Impact factor: 79.321

Review 5. Surface antigenic markers for distinguishing T and B lymphocytes in mice.

Authors: M C Raff
Journal: Transplant Rev Date: 1971

6. Purification and biological activity of thymosin, a hormone of the thymus gland.

Authors: A L Goldstein; A Guha; M M Zatz; M A Hardy; A White
Journal: Proc Natl Acad Sci U S A Date: 1972-07 Impact factor: 11.205

7. Mechanism of complement action in rosette inhibition and lymphocytotoxicity of antilymphocyte serum.

Authors: J F Bach; I Gigli; M Dardenne; J Dormont
Journal: Immunology Date: 1972-04 Impact factor: 7.397

8. Studies on some physicochemical properties of a thymus humoral factor conferring immunocompetence on lymphoid cells.

Authors: N Trainin; M Small
Journal: J Exp Med Date: 1970-11 Impact factor: 14.307

9. Induction of T lymphocytes from precursor cells in vitro by a product of the thymus.

Authors: K Komuro; E A Boyse
Journal: J Exp Med Date: 1973-08-01 Impact factor: 14.307

10. Incorporation of sulfate by the mouse thymus: its relation to secretion by medullary epithelial cells and to thymic lymphopoiesis.

Authors: S L Clark
Journal: J Exp Med Date: 1968-11-01 Impact factor: 14.307

18 in total

1. Activation of human lymphocytes by supernatants from human thymic epithelium.

Authors: J M Goust; D H Vesole; H H Fudenberg
Journal: Clin Exp Immunol Date: 1979-11 Impact factor: 4.330

2. A zinc-dependent epitope on the molecule of thymulin, a thymic hormone.

Authors: M Dardenne; W Savino; S Berrih; J F Bach
Journal: Proc Natl Acad Sci U S A Date: 1985-10 Impact factor: 11.205

3. A cloned rat thymic epithelial cell line established from serum-free selective culture.

Authors: A Piltch; P Naylor; J Hayashi
Journal: In Vitro Cell Dev Biol Date: 1988-04

4. Augmentation of mitogen responsiveness in human lymphocytes by a humoral factor obtained from thymic epithelial cultures.

Authors: E J Hensen; E C Hoefsmit; J G Van Den Tweel
Journal: Clin Exp Immunol Date: 1978-05 Impact factor: 4.330

5. The growth of nonlymphoid thymic components in vitro: age-related differences during development.

Authors: W B Milisen; G K Miller; S A Benjamin; G J Sibert
Journal: In Vitro Cell Dev Biol Date: 1988-10

6. Immunohistochemical studies on a human thymic epithelial cell subset defined by the anti-cytokeratin 18 monoclonal antibody.

Authors: W Savino; M Dardenne
Journal: Cell Tissue Res Date: 1988-10 Impact factor: 5.249