Literature DB >> 12391370

Copaxone's effect on MRI-monitored disease in relapsing MS is reproducible and sustained.

J S Wolinsky1, G Comi, M Filippi, D Ladkani, S Kadosh, G Shifroni.   

Abstract

All but 6% of the subjects with relapsing remitting MS who were randomly assigned to receive glatiramer acetate or placebo for the 9-month controlled phase of the European/Canadian MRI trial entered an open-label extension with quarterly clinical and MRI evaluations for another 9 months. There was a 54% reduction in the mean number of enhanced lesions for those converted from placebo to glatiramer acetate and an additional 24.6% reduction for those always on glatiramer acetate. Over the entire study the accumulated T2 disease burden was 34.2% less for those always on glatiramer acetate.

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Year:  2002        PMID: 12391370     DOI: 10.1212/wnl.59.8.1284

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  12 in total

Review 1.  Imaging of multiple sclerosis: role in neurotherapeutics.

Authors:  Rohit Bakshi; Alireza Minagar; Zeenat Jaisani; Jerry S Wolinsky
Journal:  NeuroRx       Date:  2005-04

Review 2.  Glatiramer acetate: a review of its use in patients with relapsing-remitting multiple sclerosis and in delaying the onset of clinically definite multiple sclerosis.

Authors:  Lesley J Scott
Journal:  CNS Drugs       Date:  2013-11       Impact factor: 5.749

Review 3.  Glatiramer acetate: a review of its use in relapsing-remitting multiple sclerosis and in delaying the onset of clinically definite multiple sclerosis.

Authors:  Natalie J Carter; Gillian M Keating
Journal:  Drugs       Date:  2010-08-20       Impact factor: 9.546

Review 4.  The Evolving Mechanisms of Action of Glatiramer Acetate.

Authors:  Thomas Prod'homme; Scott S Zamvil
Journal:  Cold Spring Harb Perspect Med       Date:  2019-02-01       Impact factor: 6.915

Review 5.  Glatiramer acetate: a review of its use in relapsing-remitting multiple sclerosis.

Authors:  Dene Simpson; Stuart Noble; Caroline Perry
Journal:  CNS Drugs       Date:  2002       Impact factor: 5.749

Review 6.  Glatiramer acetate: evidence for a dual mechanism of action.

Authors:  François Blanchette; Oliver Neuhaus
Journal:  J Neurol       Date:  2008-03       Impact factor: 4.849

Review 7.  The search for a balance between short and long-term treatment outcomes in multiple sclerosis.

Authors:  Ulf Baumhackl
Journal:  J Neurol       Date:  2008-03       Impact factor: 4.849

Review 8.  Immunomodulatory treatment strategies in multiple sclerosis.

Authors:  Bernd C Kieseier; Heinz Wiendl; Verena I Leussink; Olaf Stüve
Journal:  J Neurol       Date:  2008-12       Impact factor: 4.849

9.  Glatiramer acetate in the treatment of multiple sclerosis.

Authors:  Alex Tselis; Omar Khan; Robert P Lisak
Journal:  Neuropsychiatr Dis Treat       Date:  2007-04       Impact factor: 2.570

Review 10.  Glatiramer in the treatment of multiple sclerosis.

Authors:  Syed A Rizvi; Edward Kim; Jennifer Moodie
Journal:  Int J Nanomedicine       Date:  2006
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