Literature DB >> 12379737

Multiparameter selection of Helicobacter pylori antigens identifies two novel antigens with high protective efficacy.

N Sabarth1, R Hurwitz, T F Meyer, D Bumann.   

Abstract

A multiparameter selection of Helicobacter pylori antigens for vaccine development identified 15 candidates, 6 of which are known protective antigens. Two novel antigens with low homology to other organisms (HP0231 and HP0410) were overexpressed and purified with high yields. Both confer protective immunity in the mouse Helicobacter infection model.

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Year:  2002        PMID： 12379737      PMCID： PMC130322          DOI： 10.1128/IAI.70.11.6499-6503.2002

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  37 in total

1.  Acidic pH changes receptor binding specificity of Helicobacter pylori: a binary adhesion model in which surface heat shock (stress) proteins mediate sulfatide recognition in gastric colonization.

Authors:  M Huesca; S Borgia; P Hoffman; C A Lingwood
Journal:  Infect Immun       Date:  1996-07       Impact factor: 3.441

2.  The complete genome sequence of the gastric pathogen Helicobacter pylori.

Authors:  J F Tomb; O White; A R Kerlavage; R A Clayton; G G Sutton; R D Fleischmann; K A Ketchum; H P Klenk; S Gill; B A Dougherty; K Nelson; J Quackenbush; L Zhou; E F Kirkness; S Peterson; B Loftus; D Richardson; R Dodson; H G Khalak; A Glodek; K McKenney; L M Fitzegerald; N Lee; M D Adams; E K Hickey; D E Berg; J D Gocayne; T R Utterback; J D Peterson; J M Kelley; M D Cotton; J M Weidman; C Fujii; C Bowman; L Watthey; E Wallin; W S Hayes; M Borodovsky; P D Karp; H O Smith; C M Fraser; J C Venter
Journal:  Nature       Date:  1997-08-07       Impact factor: 49.962

3.  An empirical method for the prediction of T-cell epitopes.

Authors:  M P Davenport; I A Ho Shon; A V Hill
Journal:  Immunogenetics       Date:  1995       Impact factor: 2.846

Review 4.  Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity.

Authors:  R M Zinkernagel; S Ehl; P Aichele; S Oehen; T Kündig; H Hengartner
Journal:  Immunol Rev       Date:  1997-04       Impact factor: 12.988

5.  Two novel T cell epitope prediction algorithms based on MHC-binding motifs; comparison of predicted and published epitopes from Mycobacterium tuberculosis and HIV protein sequences.

Authors:  G E Meister; C G Roberts; J A Berzofsky; A S De Groot
Journal:  Vaccine       Date:  1995-04       Impact factor: 3.641

6.  Neutrophil-activating protein mediates adhesion of Helicobacter pylori to sulfated carbohydrates on high-molecular-weight salivary mucin.

Authors:  F Namavar; M Sparrius; E C Veerman; B J Appelmelk; C M Vandenbroucke-Grauls
Journal:  Infect Immun       Date:  1998-02       Impact factor: 3.441

7.  Catalase, a novel antigen for Helicobacter pylori vaccination.

Authors:  F J Radcliff; S L Hazell; T Kolesnikow; C Doidge; A Lee
Journal:  Infect Immun       Date:  1997-11       Impact factor: 3.441

8.  Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis.

Authors:  S H Phadnis; M H Parlow; M Levy; D Ilver; C M Caulkins; J B Connors; B E Dunn
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

9.  Immunization of BALB/c mice against Helicobacter felis infection with Helicobacter pylori urease.

Authors:  P Michetti; I Corthésy-Theulaz; C Davin; R Haas; A C Vaney; M Heitz; J Bille; J P Kraehenbuhl; E Saraga; A L Blum
Journal:  Gastroenterology       Date:  1994-10       Impact factor: 22.682

10.  Development of a mouse model of Helicobacter pylori infection that mimics human disease.

Authors:  M Marchetti; B Aricò; D Burroni; N Figura; R Rappuoli; P Ghiara
Journal:  Science       Date:  1995-03-17       Impact factor: 47.728
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  11 in total

1.  Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen.

Authors:  Claudia Rollenhagen; Meike Sörensen; Konstantin Rizos; Robert Hurvitz; Dirk Bumann
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-01       Impact factor: 11.205

Review 2.  Two-dimensional gel electrophoresis in bacterial proteomics.

Authors:  Shirly O T Curreem; Rory M Watt; Susanna K P Lau; Patrick C Y Woo
Journal:  Protein Cell       Date:  2012-05-18       Impact factor: 14.870

Review 3.  Structural and functional aspects of the Helicobacter pylori secretome.

Authors:  Giuseppe Zanotti; Laura Cendron
Journal:  World J Gastroenterol       Date:  2014-02-14       Impact factor: 5.742

4.  Oral immunization with recombinant Lactobacillus acidophilus expressing the adhesin Hp0410 of Helicobacter pylori induces mucosal and systemic immune responses.

Authors:  Fan Hongying; Wu Xianbo; Yu Fang; Bai Yang; Long Beiguo
Journal:  Clin Vaccine Immunol       Date:  2013-11-27

5.  Detection and evaluation of antibodies against neutrophil-activating protein of Helicobacter pylori in patients with gastric cancer.

Authors:  Min Long; Jun Luo; Yan Li; Fang-Yin Zeng; Ming Li
Journal:  World J Gastroenterol       Date:  2009-05-21       Impact factor: 5.742

6.  Transgenic, fluorescent Leishmania mexicana allow direct analysis of the proteome of intracellular amastigotes.

Authors:  Daniel Paape; Christoph Lippuner; Monika Schmid; Renate Ackermann; Martin E Barrios-Llerena; Ursula Zimny-Arndt; Volker Brinkmann; Benjamin Arndt; Klaus Peter Pleissner; Peter R Jungblut; Toni Aebischer
Journal:  Mol Cell Proteomics       Date:  2008-05-12       Impact factor: 5.911

7.  Growth phase-dependent composition of the Helicobacter pylori exoproteome.

Authors:  Christina A Snider; Bradley J Voss; W Hayes McDonald; Timothy L Cover
Journal:  J Proteomics       Date:  2015-09-09       Impact factor: 4.044

8.  Tip-alpha (hp0596 gene product) is a highly immunogenic Helicobacter pylori protein involved in colonization of mouse gastric mucosa.

Authors:  Renata Godlewska; Marcin Pawlowski; Artur Dzwonek; Michal Mikula; Jerzy Ostrowski; Nadzieja Drela; Elzbieta K Jagusztyn-Krynicka
Journal:  Curr Microbiol       Date:  2008-01-03       Impact factor: 2.188

9.  A novel insight into the oxidoreductase activity of Helicobacter pylori HP0231 protein.

Authors:  Paula Roszczenko; Katarzyna A Radomska; Ewa Wywial; Jean-Francois Collet; Elzbieta K Jagusztyn-Krynicka
Journal:  PLoS One       Date:  2012-10-03       Impact factor: 3.240

10.  Single dose novel Salmonella vaccine enhances resistance against visceralizing L. major and L. donovani infection in susceptible BALB/c mice.

Authors:  Juliane Schroeder; Najmeeyah Brown; Paul Kaye; Toni Aebischer
Journal:  PLoS Negl Trop Dis       Date:  2011-12-27
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