| Literature DB >> 9252185 |
J F Tomb1, O White, A R Kerlavage, R A Clayton, G G Sutton, R D Fleischmann, K A Ketchum, H P Klenk, S Gill, B A Dougherty, K Nelson, J Quackenbush, L Zhou, E F Kirkness, S Peterson, B Loftus, D Richardson, R Dodson, H G Khalak, A Glodek, K McKenney, L M Fitzegerald, N Lee, M D Adams, E K Hickey, D E Berg, J D Gocayne, T R Utterback, J D Peterson, J M Kelley, M D Cotton, J M Weidman, C Fujii, C Bowman, L Watthey, E Wallin, W S Hayes, M Borodovsky, P D Karp, H O Smith, C M Fraser, J C Venter.
Abstract
Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.Entities:
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Year: 1997 PMID： 9252185 DOI： 10.1038/41483
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962