Literature DB >> 7886456

Development of a mouse model of Helicobacter pylori infection that mimics human disease.

M Marchetti1, B Aricò, D Burroni, N Figura, R Rappuoli, P Ghiara.   

Abstract

The human pathogen Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. The pathogenesis of H. pylori infection in vivo was studied by adapting fresh clinical isolates of bacteria to colonize the stomachs of mice. A gastric pathology resembling human disease was observed in infections with cytotoxin-producing strains but not with noncytotoxic strains. Oral immunization with purified H. pylori antigens protected mice from bacterial infection. This mouse model will allow the development of therapeutic agents and vaccines against H. pylori infection in humans.

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Year:  1995        PMID： 7886456     DOI： 10.1126/science.7886456

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  159 in total

1.  Incidence of Helicobacter pylori infection in a cohort of Italian military students.

Authors:  R Biselli; M Fortini; P M Matricardi; T Stroffolini; R D'Amelio
Journal:  Infection       Date:  1999 May-Jun       Impact factor: 3.553

2.  Mutational analysis of the Helicobacter pylori vacuolating toxin amino terminus: identification of amino acids essential for cellular vacuolation.

Authors:  D Ye; S R Blanke
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

3.  Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model.

Authors:  A M Kabir; Y Aiba; A Takagi; S Kamiya; T Miwa; Y Koga
Journal:  Gut       Date:  1997-07       Impact factor: 23.059

4.  Platelet activation In mice and human Helicobacter pylori infection.

Authors:  J I Elizalde; J Gómez; J Panés; M Lozano; M Casadevall; J Ramírez; P Pizcueta; F Marco; F D Rojas; D N Granger; J M Piqué
Journal:  J Clin Invest       Date:  1997-09-01       Impact factor: 14.808

5.  Comparative analysis of colonization of Helicobacter pylori and glycolipids receptor density in Mongolian gerbils and mice.

Authors:  H Osawa; K Sugano; M Iwamori; M Kawakami; M Tada; M Nakao
Journal:  Dig Dis Sci       Date:  2001-01       Impact factor: 3.199

6.  High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori.

Authors:  P Cao; T L Cover
Journal:  J Bacteriol       Date:  1997-05       Impact factor: 3.490

7.  Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation.

Authors:  M Stein; R Rappuoli; A Covacci
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

8.  Plasma membrane cholesterol modulates cellular vacuolation induced by the Helicobacter pylori vacuolating cytotoxin.

Authors:  Hetal K Patel; David C Willhite; Rakhi M Patel; Dan Ye; Christopher L Williams; Eric M Torres; Kent B Marty; Robert A MacDonald; Steven R Blanke
Journal:  Infect Immun       Date:  2002-08       Impact factor: 3.441

9.  Fluorescence resonance energy transfer microscopy of the Helicobacter pylori vacuolating cytotoxin within mammalian cells.

Authors:  David C Willhite; Dan Ye; Steven R Blanke
Journal:  Infect Immun       Date:  2002-07       Impact factor: 3.441

10.  Endosome-mitochondria juxtaposition during apoptosis induced by H. pylori VacA.

Authors:  F Calore; C Genisset; A Casellato; M Rossato; G Codolo; M D Esposti; L Scorrano; M de Bernard
Journal:  Cell Death Differ       Date:  2010-04-30       Impact factor: 15.828
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