Literature DB >> 12375897

A simple method for electrophilic functionalization of DNA.

Gregory P Miller1, Eric T Kool.   

Abstract

[reaction: see text] An extremely simple and versatile method for placing an electrophilic functional group (iodide) at the 5' end of oligodeoxyribonucleotides is described. The reaction is carried out while the protected oligodeoxyribonucleotide remains on a solid support and utilizes inexpensive iodination chemistry. We demonstrate that this reaction can be automated on a DNA synthesizer as the last step of DNA synthesis.

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Year:  2002        PMID： 12375897     DOI： 10.1021/ol0264915

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  5 in total

1.  Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli.

Authors:  Afaf H El-Sagheer; A Pia Sanzone; Rachel Gao; Ali Tavassoli; Tom Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2011-06-27       Impact factor: 11.205

2.  Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers.

Authors:  Neal K Devaraj; Gregory P Miller; Wataru Ebina; Boyko Kakaradov; James P Collman; Eric T Kool; Christopher E D Chidsey
Journal:  J Am Chem Soc       Date:  2005-06-22       Impact factor: 15.419

3.  Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA.

Authors:  Pawan Kumar; Afaf H El-Sagheer; Lynda Truong; Tom Brown
Journal:  Chem Commun (Camb)       Date:  2017-08-03       Impact factor: 6.222

4.  Late-Stage Functionalisation of Peptides on the Solid Phase by an Iodination-Substitution Approach.

Authors:  Marius Werner; Julius Pampel; Truc Lam Pham; Franziska Thomas
Journal:  Chemistry       Date:  2022-07-20       Impact factor: 5.020

5.  Assessing the biocompatibility of click-linked DNA in Escherichia coli.

Authors:  A Pia Sanzone; Afaf H El-Sagheer; Tom Brown; Ali Tavassoli
Journal:  Nucleic Acids Res       Date:  2012-08-16       Impact factor: 16.971
  5 in total

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