| Literature DB >> 12372533 |
E Scott Priestley1, Indawati De Lucca, Bahman Ghavimi, Susan Erickson-Viitanen, Carl P Decicco.
Abstract
A series of peptide boronic acids containing extended, hydrophobic P1 residues was prepared to probe the shallow, hydrophobic S1 region of HCV NS3 protease. The p-trifluoromethylphenethyl P1 substituent was identified as optimal with respect to inhibitor potency for NS3 and selectivity against elastase and chymotrypsin.Entities:
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Year: 2002 PMID： 12372533 DOI： 10.1016/s0960-894x(02)00682-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823