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Literature DB >> 23412370

Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA.

Wenyu Zhang¹, David I Bryson, Jason B Crumpton, Jessica Wynn, Webster L Santos.

Abstract

We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2013 PMID： 23412370 PMCID： PMC3601739 DOI： 10.1039/c3cc00243h

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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12 in total

1. Molecular recognition of HIV-1 RNAs with branched peptides.

Authors: Ashley N Peralta; Yumin Dai; Chringma Sherpa; Stuart F J Le Grice; Webster L Santos
Journal: Methods Enzymol Date: 2019-05-15 Impact factor: 1.600

2. Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA.

Authors: Yumin Dai; Ashley N Peralta; Jessica E Wynn; Chringma Sherpa; Hao Li; Astha Verma; Stuart F J Le Grice; Webster L Santos
Journal: Bioorg Med Chem Date: 2019-03-07 Impact factor: 3.641

3. HIV-1 drug discovery: targeting folded RNA structures with branched peptides.

Authors: Jessica E Wynn; Webster L Santos
Journal: Org Biomol Chem Date: 2015-06-07 Impact factor: 3.876

4. An efficient methodology to introduce o-(aminomethyl)phenyl-boronic acids into peptides: alkylation of secondary amines.

Authors: Erik T Hernandez; Igor V Kolesnichenko; James F Reuther; Eric V Anslyn
Journal: New J Chem Date: 2016-11-17 Impact factor: 3.591

5. Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication.

Authors: Yumin Dai; Jessica E Wynn; Ashley N Peralta; Chringma Sherpa; Bhargavi Jayaraman; Hao Li; Astha Verma; Alan D Frankel; Stuart F Le Grice; Webster L Santos
Journal: J Med Chem Date: 2018-10-18 Impact factor: 7.446

6. Effect of intercalator and Lewis acid-base branched peptide complex formation: boosting affinity towards HIV-1 RRE RNA.

Authors: Jessica E Wynn; Wenyu Zhang; Denis M Tebit; Laurie R Gray; Marie-Louise Hammarskjold; David Rekosh; Webster L Santos
Journal: Medchemcomm Date: 2016-06-06 Impact factor: 3.597