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Literature DB >> 12368844

Acrylamide is formed in the Maillard reaction.

Donald S Mottram¹, Bronislaw L Wedzicha, Andrew T Dodson.

Abstract

Reports of the presence of acrylamide in a range of fried and oven-cooked foods have caused worldwide concern because this compound has been classified as probably carcinogenic in humans. Here we show how acrylamide can be generated from food components during heat treatment as a result of the Maillard reaction between amino acids and reducing sugars. We find that asparagine, a major amino acid in potatoes and cereals, is a crucial participant in the production of acrylamide by this pathway.

Entities: Chemical Disease Species

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Year: 2002 PMID： 12368844 DOI： 10.1038/419448a

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

155 in total

1. Characterization of Acrylamidase isolated from a newly isolated acrylamide-utilizing bacterium, Ralstonia eutropha AUM-01.

Authors: Minseok Cha; Glenn H Chambliss
Journal: Curr Microbiol Date: 2010-09-25 Impact factor: 2.188

2. Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure.

Authors: Frederick A Beland; Greg R Olson; Maria C B Mendoza; M Matilde Marques; Daniel R Doerge
Journal: Food Chem Toxicol Date: 2015-09-30 Impact factor: 6.023

3. Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide.

Authors: Francesco Marchetti; Jack Bishop; Xiu Lowe; Andrew J Wyrobek
Journal: Toxicol Sci Date: 2008-10-16 Impact factor: 4.849

4. Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.

Authors: Nan Mei; Lei Guo; Jo Tseng; Stacey L Dial; Wayne Liao; Mugimane G Manjanatha
Journal: Environ Mol Mutagen Date: 2008-12 Impact factor: 3.216

5. Photoheterotrophic metabolism of acrylamide by a newly isolated strain of Rhodopseudomonas palustris.

Authors: David A Wampler; Scott A Ensign
Journal: Appl Environ Microbiol Date: 2005-10 Impact factor: 4.792

6. Dietary acrylamide exposure was associated with increased cancer mortality in Chinese elderly men and women: a 11-year prospective study of Mr. and Ms. OS Hong Kong.

Authors: Zhao-Min Liu; Lap Ah Tse; Suzanne C Ho; Suyang Wu; Bailing Chen; Dicken Chan; Samuel Yeung-Shan Wong
Journal: J Cancer Res Clin Oncol Date: 2017-07-19 Impact factor: 4.553

Acrylamide is formed in the Maillard reaction.

1. Characterization of Acrylamidase isolated from a newly isolated acrylamide-utilizing bacterium, Ralstonia eutropha AUM-01.

2. Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure.

3. Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide.

4. Gene expression changes associated with xenobiotic metabolism pathways in mice exposed to acrylamide.

5. Photoheterotrophic metabolism of acrylamide by a newly isolated strain of Rhodopseudomonas palustris.

6. Dietary acrylamide exposure was associated with increased cancer mortality in Chinese elderly men and women: a 11-year prospective study of Mr. and Ms. OS Hong Kong.

7. Role of endoplasmic reticulum stress in acrolein-induced endothelial activation.

Review 8. Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease.

9. Biomarkers of human exposure to acrylamide and relation to polymorphisms in metabolizing genes.

10. Low-acrylamide French fries and potato chips.