Literature DB >> 12362369

The first orally active low molecular weight agonists for the LH receptor: thienopyr(im)idines with therapeutic potential for ovulation induction.

N C R van Straten1, G G Schoonus-Gerritsma, R G van Someren, J Draaijer, A E P Adang, C M Timmers, R G J M Hanssen, C A A van Boeckel.   

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Year:  2002        PMID： 12362369     DOI： 10.1002/1439-7633(20021004)3:10<1023::AID-CBIC1023>3.0.CO;2-9

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


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  22 in total

1.  The Synthesis and Evaluation of Dihydroquinazolin-4-ones and Quinazolin-4-ones as Thyroid Stimulating Hormone Receptor Agonists.

Authors:  Erika E Englund; Susanne Neumann; Elena Eliseeva; Joshua G McCoy; Steven Titus; Wei Zheng; Noel Southall; Paul Shin; William Leister; Craig J Thomas; James Inglese; Christopher P Austin; Marvin C Gershengorn; Wenwei Huang
Journal:  Medchemcomm       Date:  2011-10       Impact factor: 3.597

2.  A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor.

Authors:  Chris J van Koppen; Guido J R Zaman; C Marco Timmers; Jan Kelder; Sietse Mosselman; Ruud van de Lagemaat; Martin J Smit; Rob G J M Hanssen
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-06-13       Impact factor: 3.000

Review 3.  Are circulating gonadotropin isoforms naturally occurring biased agonists? Basic and therapeutic implications.

Authors:  Brian J Arey; Francisco J López
Journal:  Rev Endocr Metab Disord       Date:  2011-12       Impact factor: 6.514

Review 4.  Novel pathways in gonadotropin receptor signaling and biased agonism.

Authors:  Alfredo Ulloa-Aguirre; Pascale Crépieux; Anne Poupon; Marie-Christine Maurel; Eric Reiter
Journal:  Rev Endocr Metab Disord       Date:  2011-12       Impact factor: 6.514

5.  Intratesticular, intraperitoneal, and oral administration of thienopyrimidine derivatives increases the testosterone level in male rats.

Authors:  K V Derkach; D V Dar'in; P S Lobanov; A O Shpakov
Journal:  Dokl Biol Sci       Date:  2015-01-06

Review 6.  Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.

Authors:  Alfredo Ulloa-Aguirre; Teresa Zariñán; James A Dias; P Michael Conn
Journal:  Mol Cell Endocrinol       Date:  2013-06-24       Impact factor: 4.102

7.  The stimulating influence of thienopyrimidine compounds on the adenylyl cyclase signaling systems in the rat testes.

Authors:  A O Shpakov; D V Dar'in; K V Derkach; P S Lobanov
Journal:  Dokl Biochem Biophys       Date:  2014-07-04       Impact factor: 0.788

8.  Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist.

Authors:  Claire L Newton; Adele M Whay; Craig A McArdle; Meilin Zhang; Chris J van Koppen; Ruud van de Lagemaat; Deborah L Segaloff; Robert P Millar
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-11       Impact factor: 11.205

9.  Evaluation of small-molecule modulators of the luteinizing hormone/choriogonadotropin and thyroid stimulating hormone receptors: structure-activity relationships and selective binding patterns.

Authors:  Susanna Moore; Holger Jaeschke; Gunnar Kleinau; Susanne Neumann; Stefano Costanzi; Jian-kang Jiang; John Childress; Bruce M Raaka; Anny Colson; Ralf Paschke; Gerd Krause; Craig J Thomas; Marvin C Gershengorn
Journal:  J Med Chem       Date:  2006-06-29       Impact factor: 7.446

10.  Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist.

Authors:  Kimberly M Bonger; Sascha Hoogendoorn; Chris J van Koppen; C Marco Timmers; Gijsbert A van der Marel; Herman S Overkleeft
Journal:  ACS Med Chem Lett       Date:  2010-11-08       Impact factor: 4.345
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