Literature DB >> 1236156

On the deposition of unipolarly charged particles in the human respiratory tract.

C Melandri, V Prodi, G Tarroni, M Formignani, T De Zaiacomo, G F Bompane, G Maestri.   

Abstract

The effect of unipolar electrostatic charges on the total deposition efficiency in the human respiratory tract has been investigated. Monodisperse carnauba wax particles of diameter between 0.3 and 1.1 micron were charged, in a corona discharge apparatus, with a number of elementary charges ranging from about 30 to 110 per particle, with a narrow distribution. The experiments were performed with volunteers breathing through the mouth at 12 resp/min at constant flow rate, without pauses. The increase in deposition was of the order of 15 to 30% relative to neutral but otherwise unchanged monodisperse aerosol. The increase depended on the charges carried by each particle, but was independent of the concentration. Therefore it may be concluded that the variation can be ascribed to the effect of electrostatic attraction between the particle charge and the image charge on the airway wall.

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Year:  1975        PMID: 1236156

Source DB:  PubMed          Journal:  Inhaled Part        ISSN: 0301-1577


  7 in total

1.  Precipitation of submicron charged particles in human lung airways.

Authors:  C P Yu; K Chandra
Journal:  Bull Math Biol       Date:  1977       Impact factor: 1.758

2.  Production of Highly Charged Pharmaceutical Aerosols Using a New Aerosol Induction Charger.

Authors:  Laleh Golshahi; P Worth Longest; Landon Holbrook; Jessica Snead; Michael Hindle
Journal:  Pharm Res       Date:  2015-03-31       Impact factor: 4.200

3.  The Effect of Active Pharmaceutical Ingredients on Aerosol Electrostatic Charges from Pressurized Metered Dose Inhalers.

Authors:  Yang Chen; Paul M Young; David F Fletcher; Hak Kim Chan; Edward Long; David Lewis; Tanya Church; Daniela Traini
Journal:  Pharm Res       Date:  2015-03-19       Impact factor: 4.200

4.  Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation, and avoiding multiple actuations of drug.

Authors:  C O'Callaghan; J Lynch; M Cant; C Robertson
Journal:  Thorax       Date:  1993-06       Impact factor: 9.139

5.  Effect of Relative Humidity on Bipolar Electrostatic Charge Profiles of dry Powder Aerosols.

Authors:  Jiaqi Yu; Jennifer Wong; Ari Ukkonen; Jonna Kannosto; Hak-Kim Chan
Journal:  Pharm Res       Date:  2017-05-24       Impact factor: 4.200

6.  Applicability of Bipolar Charge Analyzer (BOLAR) in Characterizing the Bipolar Electrostatic Charge Profile of Commercial Metered Dose Inhalers (MDIs).

Authors:  Sharon Shui Yee Leung; Adam Chong Ming Chiow; Ari Ukkonen; Hak-Kim Chan
Journal:  Pharm Res       Date:  2015-09-03       Impact factor: 4.200

7.  Effect of relative humidity on the electrostatic charge properties of dry powder inhaler aerosols.

Authors:  Philip Chi Lip Kwok; Hak-Kim Chan
Journal:  Pharm Res       Date:  2007-07-10       Impact factor: 4.200

  7 in total

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