Literature DB >> 12228721

A stem cell molecular signature.

Natalia B Ivanova1, John T Dimos, Christoph Schaniel, Jason A Hackney, Kateri A Moore, Ihor R Lemischka.   

Abstract

Mechanisms regulating self-renewal and cell fate decisions in mammalian stem cells are poorly understood. We determined global gene expression profiles for mouse and human hematopoietic stem cells and other stages of the hematopoietic hierarchy. Murine and human hematopoietic stem cells share a number of expressed gene products, which define key conserved regulatory pathways in this developmental system. Moreover, in the mouse, a portion of the genetic program of hematopoietic stem cells is shared with embryonic and neural stem cells. This overlapping set of gene products represents a molecular signature of stem cells.

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Year:  2002        PMID： 12228721     DOI： 10.1126/science.1073823

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  427 in total

1.  A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells.

Authors:  Robert Y L Tsai; Ronald D G McKay
Journal:  Genes Dev       Date:  2002-12-01       Impact factor: 11.361

2.  Gfer is a critical regulator of HSC proliferation.

Authors:  Uma Sankar; Anthony R Means
Journal:  Cell Cycle       Date:  2011-07-15       Impact factor: 4.534

3.  Perivascular human endometrial mesenchymal stem cells express pathways relevant to self-renewal, lineage specification, and functional phenotype.

Authors:  Trimble L B Spitzer; Angela Rojas; Zara Zelenko; Lusine Aghajanova; David W Erikson; Fatima Barragan; Michelle Meyer; John S Tamaresis; Amy E Hamilton; Juan C Irwin; Linda C Giudice
Journal:  Biol Reprod       Date:  2012-02-29       Impact factor: 4.285

4.  In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells.

Authors:  Gabriela Dontu; Wissam M Abdallah; Jessica M Foley; Kyle W Jackson; Michael F Clarke; Mari J Kawamura; Max S Wicha
Journal:  Genes Dev       Date:  2003-05-15       Impact factor: 11.361

5.  Defining the epithelial stem cell niche in skin.

Authors:  Tudorita Tumbar; Geraldine Guasch; Valentina Greco; Cedric Blanpain; William E Lowry; Michael Rendl; Elaine Fuchs
Journal:  Science       Date:  2003-12-11       Impact factor: 47.728

6.  Hirschsprung disease is linked to defects in neural crest stem cell function.

Authors:  Toshihide Iwashita; Genevieve M Kruger; Ricardo Pardal; Mark J Kiel; Sean J Morrison
Journal:  Science       Date:  2003-08-15       Impact factor: 47.728

7.  The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells.

Authors:  Satoru Miyagi; Tetsuichiro Saito; Ken-ichi Mizutani; Norihisa Masuyama; Yukiko Gotoh; Atsushi Iwama; Hiromitsu Nakauchi; Shinji Masui; Hitoshi Niwa; Masazumi Nishimoto; Masami Muramatsu; Akihiko Okuda
Journal:  Mol Cell Biol       Date:  2004-05       Impact factor: 4.272

8.  Comprehensive proteome expression profiling of undifferentiated versus differentiated neural stem cells from adult rat hippocampus.

Authors:  Martin H Maurer; Robert E Feldmann; Carsten D Fütterer; Jo Butlin; Wolfgang Kuschinsky
Journal:  Neurochem Res       Date:  2004-06       Impact factor: 3.996

Review 9.  Advancing insights into stem cell niche complexities with next-generation technologies.

Authors:  Nicholas Heitman; Nivedita Saxena; Michael Rendl
Journal:  Curr Opin Cell Biol       Date:  2018-07-19       Impact factor: 8.382

10.  Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors.

Authors:  Jamie M Sperger; Xin Chen; Jonathan S Draper; Jessica E Antosiewicz; Chris H Chon; Sunita B Jones; James D Brooks; Peter W Andrews; Patrick O Brown; James A Thomson
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-31       Impact factor: 11.205
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