Literature DB >> 12920301

Hirschsprung disease is linked to defects in neural crest stem cell function.

Toshihide Iwashita1, Genevieve M Kruger, Ricardo Pardal, Mark J Kiel, Sean J Morrison.   

Abstract

Genes associated with Hirschsprung disease, a failure to form enteric ganglia in the hindgut, were highly up-regulated in gut neural crest stem cells relative to whole-fetus RNA. One of these genes, the glial cell line-derived neurotrophic factor (GDNF) receptor Ret, was necessary for neural crest stem cell migration in the gut. GDNF promoted the migration of neural crest stem cells in culture but did not affect their survival or proliferation. Gene expression profiling, combined with reverse genetics and analyses of stem cell function, suggests that Hirschsprung disease is caused by defects in neural crest stem cell function.

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Year:  2003        PMID： 12920301      PMCID： PMC2614078          DOI： 10.1126/science.1085649

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  37 in total

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Journal:  Science       Date:  2000-02-25       Impact factor: 47.728

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Journal:  Cell       Date:  1999-03-05       Impact factor: 41.582

5.  A stem cell molecular signature.

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Journal:  Science       Date:  2002-09-12       Impact factor: 47.728

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Authors:  Jaesang Kim; Liching Lo; Emma Dormand; David J Anderson
Journal:  Neuron       Date:  2003-04-10       Impact factor: 17.173

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Authors:  P Edery; S Lyonnet; L M Mulligan; A Pelet; E Dow; L Abel; S Holder; C Nihoul-Fékété; B A Ponder; A Munnich
Journal:  Nature       Date:  1994-01-27       Impact factor: 49.962

8.  Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.

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Journal:  Nature       Date:  1994-01-27       Impact factor: 49.962

9.  Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system.

Authors:  S Taraviras; C V Marcos-Gutierrez; P Durbec; H Jani; M Grigoriou; M Sukumaran; L C Wang; M Hynes; G Raisman; V Pachnis
Journal:  Development       Date:  1999-06       Impact factor: 6.868

10.  Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis.

Authors:  Dipa Natarajan; Camelia Marcos-Gutierrez; Vassilis Pachnis; Esther de Graaff
Journal:  Development       Date:  2002-11       Impact factor: 6.868
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  68 in total

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Journal:  FASEB J       Date:  2020-06-27       Impact factor: 5.191

2.  Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.

Authors:  Tiffany A Heanue; Vassilis Pachnis
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-21       Impact factor: 11.205

3.  Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors.

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4.  Genetic background impacts developmental potential of enteric neural crest-derived progenitors in the Sox10Dom model of Hirschsprung disease.

Authors:  Lauren C Walters; V Ashley Cantrell; Kevin P Weller; Jack T Mosher; E Michelle Southard-Smith
Journal:  Hum Mol Genet       Date:  2010-08-25       Impact factor: 6.150

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Authors:  Jack T Mosher; Kelly J Yeager; Genevieve M Kruger; Nancy M Joseph; Mark E Hutchin; Andrzej A Dlugosz; Sean J Morrison
Journal:  Dev Biol       Date:  2006-10-24       Impact factor: 3.582

6.  A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep.

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Review 7.  The genetic and molecular bases of monogenic disorders affecting proteolytic systems.

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8.  The microenvironment in the Hirschsprung's disease gut supports myenteric plexus growth.

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9.  Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells.

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Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

Review 10.  Thyroid C-Cell Biology and Oncogenic Transformation.

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Journal:  Recent Results Cancer Res       Date:  2015
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