Literature DB >> 12201781

Improved synthesis of 2,2'-bipyrimidine.

Gábor Vlád1, István T Horváth.   

Abstract

A high-yield synthesis was developed for the preparation of 2,2'-bipyrimidine (1) using the Ullmann coupling of 2-iodopyrimidine. The new procedure was also used for the preparation of 4,4',6,6'-tetramethyl-2,2'-bipyrimidine (2) and 5,5'-dibromo-2,2'-bipyrimidine (3).

Entities:  

Year:  2002        PMID： 12201781     DOI： 10.1021/jo0255781

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  4 in total

1.  Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Authors:  Sébastien Guery; Philipp Floersheim; Klemens Kaupmann; Wolfgang Froestl
Journal:  Bioorg Med Chem Lett       Date:  2007-09-08       Impact factor: 2.823

2.  2-Iodo-3-meth-oxy-6-methyl-pyridine.

Authors:  Wenbo Guo; Xueqin Liu; Long Li; Dongsheng Deng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-11-28

3.  4,4',6,6'-Tetra-methyl-2,2'-bipyrimidine hexa-hydrate.

Authors:  Yanni Ma; Le Zhou; Dongsheng Deng; Baoming Ji
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-03-25

4.  Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment.

Authors:  Yi-Ming Shao; Xiaohua Ma; Priyankar Paira; Aaron Tan; Deron Raymond Herr; Kah Leong Lim; Chee Hoe Ng; Gopalakrishnan Venkatesan; Karl-Norbert Klotz; Stephanie Federico; Giampiero Spalluto; Siew Lee Cheong; Yu Zong Chen; Giorgia Pastorin
Journal:  PLoS One       Date:  2018-01-05       Impact factor: 3.240
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.