Literature DB >> 17884493

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Sébastien Guery1, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl.   

Abstract

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.

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Year:  2007        PMID： 17884493      PMCID： PMC2278029          DOI： 10.1016/j.bmcl.2007.09.023

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

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Review 5.  Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.

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