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Literature DB >> 12196629

Cytochrome c folding pathway: kinetic native-state hydrogen exchange.

Linh Hoang¹, Sabrina Bedard, Mallela M G Krishna, Yan Lin, S Walter Englander.

Abstract

Native-state hydrogen exchange experiments under EX1 conditions can distinguish partially unfolded intermediates by their formation rates and identify the amide hydrogens exposed and protected in each. Results obtained define a cytochrome c intermediate seen only poorly before and place it early on the major unfolding pathway. Four distinct unfolding steps are found to be kinetically ordered in the same pathway sequence inferred before.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2002 PMID： 12196629 PMCID： PMC129417 DOI： 10.1073/pnas.152439199

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

38 in total

1. An amino acid code for protein folding.

Authors: J Rumbley; L Hoang; L Mayne; S W Englander
Journal: Proc Natl Acad Sci U S A Date: 2001-01-02 Impact factor: 11.205

2. Equilibrium amide hydrogen exchange and protein folding kinetics.

Authors: Y Bai
Journal: J Biomol NMR Date: 1999-09 Impact factor: 2.835

3. The energetics of T4 lysozyme reveal a hierarchy of conformations.

Authors: M Llinás; B Gillespie; F W Dahlquist; S Marqusee
Journal: Nat Struct Biol Date: 1999-11

4. Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects.

Authors: Bryan A Krantz; Alok K Srivastava; Sehat Nauli; David Baker; Robert T Sauer; Tobin R Sosnick
Journal: Nat Struct Biol Date: 2002-06

5. A residue-specific view of the association and dissociation pathway in protein--DNA recognition.

Authors: Charalampos G Kalodimos; Rolf Boelens; Robert Kaptein
Journal: Nat Struct Biol Date: 2002-03

6. Kinetics of unfolding and folding from amide hydrogen exchange in native ubiquitin.

Authors: T Sivaraman; C B Arrington; A D Robertson
Journal: Nat Struct Biol Date: 2001-04

Review 7. Future directions in folding: the multi-state nature of protein structure.

Authors: Y Bai; S W Englander
Journal: Proteins Date: 1996-02

8. Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme.

Authors: Denis Canet; Alexander M Last; Paula Tito; Margaret Sunde; Andrew Spencer; David B Archer; Christina Redfield; Carol V Robinson; Christopher M Dobson
Journal: Nat Struct Biol Date: 2002-04

9. Studies on ferricytochrome c. 2. A correlation between reducibility and the possession of the 695mm absorption band of ferricytochrome c.

Authors: M T Wilson; C Greenwood
Journal: Eur J Biochem Date: 1971-09-13

Review 10. Hydrogen exchange in proteins.

Authors: A Hvidt; S O Nielsen
Journal: Adv Protein Chem Date: 1966

40 in total

Cytochrome c folding pathway: kinetic native-state hydrogen exchange.

1. An amino acid code for protein folding.

2. Equilibrium amide hydrogen exchange and protein folding kinetics.

3. The energetics of T4 lysozyme reveal a hierarchy of conformations.

4. Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects.

5. A residue-specific view of the association and dissociation pathway in protein--DNA recognition.

6. Kinetics of unfolding and folding from amide hydrogen exchange in native ubiquitin.

Review 7. Future directions in folding: the multi-state nature of protein structure.

8. Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme.

9. Studies on ferricytochrome c. 2. A correlation between reducibility and the possession of the 695mm absorption band of ferricytochrome c.

Review 10. Hydrogen exchange in proteins.

1. Protein hydrogen exchange mechanism: local fluctuations.

2. Protein folding: the stepwise assembly of foldon units.

3. Stability and fluctuations of amide hydrogen bonds in a bacterial cytochrome c: a molecular dynamics study.

4. A protein folding pathway with multiple folding intermediates at atomic resolution.

5. Snapshots of cytochrome c folding.

6. Native state energetics of the Src SH2 domain: evidence for a partially structured state in the denatured ensemble.

Review 7. Early events in protein folding explored by rapid mixing methods.

8. A unified mechanism for protein folding: predetermined pathways with optional errors.

9. The K79G Mutation Reshapes the Heme Crevice and Alters Redox Properties of Cytochrome c.

10. The foldon substructure of staphylococcal nuclease.