Literature DB >> 12195813

Oxidizing species in the mechanism of cytochrome P450.

Paul R Ortiz de Montellano1, James J De Voss.   

Abstract

This review discusses the mechanisms of oxygen activation by cytochrome P450 enzymes, the possible catalytic roles of the various iron--oxygen species formed in the catalytic cycle, and progress in understanding the mechanisms of hydrocarbon hydroxylation, heteroatom oxidation, and olefin epoxidation. The focus of the review is on recent results, but earlier work is discussed as appropriate. The literature through to February 2002 is surveyed, and 175 referenced are cited.

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Year:  2002        PMID： 12195813     DOI： 10.1039/b101297p

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  48 in total

Review 1.  The bioinorganic chemistry of iron in oxygenases and supramolecular assemblies.

Authors:  John T Groves
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-24       Impact factor: 11.205

2.  Oxidation of C18 Hydroxy-Polyunsaturated Fatty Acids to Epoxide or Ketone by Catalase-Related Hemoproteins Activated with Iodosylbenzene.

Authors:  Tarvi Teder; William E Boeglin; Alan R Brash
Journal:  Lipids       Date:  2017-06-19       Impact factor: 1.880

3.  On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant.

Authors:  Gianguido Coffa; Ann N Imber; Brendan C Maguire; Gurunathan Laxmikanthan; Claus Schneider; Betty J Gaffney; Alan R Brash
Journal:  J Biol Chem       Date:  2005-09-12       Impact factor: 5.157

4.  Oxoiron(IV) porphyrin pi-cation radical complexes with a chameleon behavior in cytochrome P450 model reactions.

Authors:  Woon Ju Song; Yon Ok Ryu; Rita Song; Wonwoo Nam
Journal:  J Biol Inorg Chem       Date:  2005-04-13       Impact factor: 3.358

Review 5.  Biochemical applications of ultrathin films of enzymes, polyions and DNA.

Authors:  James F Rusling; Eli G Hvastkovs; Dominic O Hull; John B Schenkman
Journal:  Chem Commun (Camb)       Date:  2007-08-30       Impact factor: 6.222

6.  Molecular design of new inhibitors of peroxidase activity of cytochrome c/cardiolipin complexes: fluorescent oxadiazole-derivatized cardiolipin.

Authors:  G G Borisenko; A A Kapralov; V A Tyurin; A Maeda; D A Stoyanovsky; V E Kagan
Journal:  Biochemistry       Date:  2008-12-23       Impact factor: 3.162

Review 7.  Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.

Authors:  Christopher J Thibodeaux; Wei-chen Chang; Hung-wen Liu
Journal:  Chem Rev       Date:  2011-10-21       Impact factor: 60.622

8.  Biosynthesis of hexahydroxyperylenequinone melanin via oxidative aryl coupling by cytochrome P-450 in Streptomyces griseus.

Authors:  Nobutaka Funa; Masanori Funabashi; Yasuo Ohnishi; Sueharu Horinouchi
Journal:  J Bacteriol       Date:  2005-12       Impact factor: 3.490

9.  Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies.

Authors:  Roman Davydov; Andrey A Gilep; Natallia V Strushkevich; Sergey A Usanov; Brian M Hoffman
Journal:  J Am Chem Soc       Date:  2012-10-05       Impact factor: 15.419

Review 10.  Biosynthesis and function of polyacetylenes and allied natural products.

Authors:  Robert E Minto; Brenda J Blacklock
Journal:  Prog Lipid Res       Date:  2008-03-13       Impact factor: 16.195
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