Literature DB >> 12192128

New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities.

Muhammad Nadeem Akhtar, Muhammad Iqbal Choudhary, Yoshisuke Tsuda, Bilge Sener, Assad Khalid, Masood Parvez.   

Abstract

Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity.

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Year:  2002        PMID： 12192128     DOI： 10.1248/cpb.50.1013

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  7 in total

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Authors:  Mei-Ling Xiang; Bin-Yuan Hu; Zi-Heng Qi; Xiao-Na Wang; Tian-Zhen Xie; Zhao-Jie Wang; Dan-Yu Ma; Qi Zeng; Xiao-Dong Luo
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Review 4.  Bulb Dormancy In Vitro-Fritillaria meleagris: Initiation, Release and Physiological Parameters.

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6.  Antioxidant and acetylcholinesterase inhibition properties of Amorpha fruticosa L. and Phytolacca americana L.

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Journal:  Pharmacogn Mag       Date:  2013-04       Impact factor: 1.085

7.  Dual Regulation of Cell Death and Cell Survival upon Induction of Cellular Stress by Isopimara-7,15-Dien-19-Oic Acid in Cervical Cancer, HeLa Cells In vitro.

Authors:  Nadiah Abu; Swee K Yeap; Ahmad Z Mat Pauzi; M Nadeem Akhtar; Nur R Zamberi; Jamil Ismail; Seema Zareen; Noorjahan B Alitheen
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  7 in total

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