| Literature DB >> 12183264 |
Christophe De Champs1, Laurent Poirel, Richard Bonnet, Danielle Sirot, Catherine Chanal, Jacques Sirot, Patrice Nordmann.
Abstract
In 2000, at the Université d'Auvergne teaching hospital in Clermont-Ferrand, France, 44 (6.2%) strains of Pseudomonas aeruginosa were found to be resistant to ceftazidime. After genotyping, 34 strains were selected. Nine had an additional beta-lactamase: OXA-21 (n = 6), PSE-1 (CARB-2) (n = 2), or PER-1 (n = 1). Ceftazidime resistance was related solely to the overproduction of the cephalosporinase in 30 strains. Sequencing of five bla(AmpC) genes encoding cephalosporinases with different pIs showed 99% identity with the ampC gene of P. aeruginosa PAO1.Entities:
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Year: 2002 PMID: 12183264 PMCID: PMC127436 DOI: 10.1128/AAC.46.9.3031-3034.2002
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191