Literature DB >> 12183109

Measurement of glucose consumption using [(18)F]fluorodeoxyglucose.

Klaus Wienhard1.   

Abstract

The [(18)F]fluorodeoxyglucose (FDG) method to measure glucose metabolism quantitatively in humans is reviewed. The assumptions and the mathematical formulation of the underlying autoradiographic Sokoloff model and its adaptation to positron emission tomography (PET) are described. Various implementations to estimate glucose consumption from measured tissue activity with PET are presented. The dependence on the "lumped constant" and on the accuracy of the input function is discussed. Recommendations for the practical application of different procedures for performing FDG studies are given.

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Year:  2002        PMID: 12183109     DOI: 10.1016/s1046-2023(02)00077-4

Source DB:  PubMed          Journal:  Methods        ISSN: 1046-2023            Impact factor:   3.608


  24 in total

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