Literature DB >> 12147932

Should beta blockers be used in the treatment of hypertension in the elderly?

L Michael Prisant1.   

Abstract

The lack of benefit and the potential negative side effects of beta blockers are overstated, especially in the elderly. This emphasis has led to recommendations by some investigators that these agents not be used in the management of hypertension in this age group. There are numerous reasons why these recommendations should not be followed. The use of beta blockers in the elderly hypertensive has resulted in a reduction in strokes and congestive heart failure. In addition, it should be emphasized that elderly patients are more likely to have silent coronary artery disease or sustain myocardial infarctions. There is abundant evidence that beta blockers are effective therapy in reducing mortality once a myocardial infarction has occurred. In fact, there is a clear reduction in sudden cardiac death. Furthermore, national statistics document that elderly patients have a prevalence of congestive heart failure that varies from 6%-10%. Multiple studies have now documented that beta blockers are additive to angiotensin-converting enzyme inhibitors in reducing mortality for congestive heart failure. Thus, elderly hypertensive patients may benefit from the use of beta blockers, especially if there is evidence of ischemic heart disease, cardiac arrhythmias, or congestive heart failure. Copyright 2002 Le Jacq Communications, Inc.

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Year:  2002        PMID: 12147932      PMCID: PMC8101853          DOI: 10.1111/j.1524-6175.2002.01250.x

Source DB:  PubMed          Journal:  J Clin Hypertens (Greenwich)        ISSN: 1524-6175            Impact factor:   3.738


  80 in total

1.  Effect of bisoprolol on blood pressure and arterial hemodynamics in systemic hypertension.

Authors:  R G Asmar; J C Kerihuel; X J Girerd; M E Safar
Journal:  Am J Cardiol       Date:  1991-07-01       Impact factor: 2.778

2.  Treatment of isolated systolic hypertension with labetalol in the elderly.

Authors:  T D Giles; M Weber; D W Bartels; H M Silberman; L P Gilderman; J F Burris
Journal:  Arch Intern Med       Date:  1990-05

3.  Self Reported Sexual Dysfunction in Men and Women Treated With Bisoprolol, Hydrochlorothiazide, Enalapril, Amlodipine, Placebo, or Bisoprolol/Hydrochlorothiazide.

Authors:  L. Michael Prisant; Matthew R. Weir; William H. Frishman; Joel M. Neutel; Michael E. Davidov; Andrew J. Lewin
Journal:  J Clin Hypertens (Greenwich)       Date:  1999-07       Impact factor: 3.738

4.  Sexual activity in hypertensive men treated with valsartan or carvedilol: a crossover study.

Authors:  R Fogari; A Zoppi; L Poletti; G Marasi; A Mugellini; L Corradi
Journal:  Am J Hypertens       Date:  2001-01       Impact factor: 2.689

5.  Reversal of left ventricular hypertrophy in essential hypertension. A meta-analysis of randomized double-blind studies.

Authors:  R E Schmieder; P Martus; A Klingbeil
Journal:  JAMA       Date:  1996-05-15       Impact factor: 56.272

6.  Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study.

Authors:  L Hansson; L H Lindholm; T Ekbom; B Dahlöf; J Lanke; B Scherstén; P O Wester; T Hedner; U de Faire
Journal:  Lancet       Date:  1999-11-20       Impact factor: 79.321

7.  Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.

Authors: 
Journal:  JAMA       Date:  1991-06-26       Impact factor: 56.272

8.  The effects of propranolol on cognitive function and quality of life: a randomized trial among patients with diastolic hypertension.

Authors:  E J Pérez-Stable; R Halliday; P S Gardiner; R B Baron; W W Hauck; M Acree; T J Coates
Journal:  Am J Med       Date:  2000-04-01       Impact factor: 4.965

9.  MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

Authors: 
Journal:  Br Med J (Clin Res Ed)       Date:  1985-07-13

10.  First-line therapy option with low-dose bisoprolol fumarate and low-dose hydrochlorothiazide in patients with stage I and stage II systemic hypertension.

Authors:  W H Frishman; J F Burris; W J Mroczek; M R Weir; D Alemayehu; J S Simon; S Y Chen; B S Bryzinski
Journal:  J Clin Pharmacol       Date:  1995-02       Impact factor: 3.126

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