Literature DB >> 12120411

Cytochrome P450 enzymes in the generation of commercial products.

F Peter Guengerich1.   

Abstract

Cytochrome P450 enzymes are remarkably diverse oxygenation catalysts that are found throughout nature. Although most of the interest in the pharmaceutical industry has focused on the role of cytochrome P450s in drug development, these enzymes also offer potential in the discovery not only of drugs, but also of other useful chemicals. Potential applications range from the use of cytochrome P450s as drug targets, to the use of randomly generated mutants of cytochrome P450s to produce libraries of new chemicals and drugs.

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Year:  2002        PMID: 12120411     DOI: 10.1038/nrd792

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN: 1474-1776            Impact factor:   84.694


  42 in total

Review 1.  P450 monooxygenases (P450ome) of the model white rot fungus Phanerochaete chrysosporium.

Authors:  Khajamohiddin Syed; Jagjit S Yadav
Journal:  Crit Rev Microbiol       Date:  2012-05-25       Impact factor: 7.624

2.  Regio- and stereospecificity of filipin hydroxylation sites revealed by crystal structures of cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis.

Authors:  Lian-Hua Xu; Shinya Fushinobu; Satoshi Takamatsu; Takayoshi Wakagi; Haruo Ikeda; Hirofumi Shoun
Journal:  J Biol Chem       Date:  2010-04-07       Impact factor: 5.157

Review 3.  Enzymatic functionalization of carbon-hydrogen bonds.

Authors:  Jared C Lewis; Pedro S Coelho; Frances H Arnold
Journal:  Chem Soc Rev       Date:  2010-11-15       Impact factor: 54.564

4.  Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli.

Authors:  Robert B Vail; Michael J Homann; Imad Hanna; Aleksey Zaks
Journal:  J Ind Microbiol Biotechnol       Date:  2005-03-01       Impact factor: 3.346

Review 5.  [Effect of intestinal cytochrome P450 3A on phytochemical presystemic metabolism].

Authors:  Fang Xia; Xiao-yin Chen
Journal:  Chin J Integr Med       Date:  2005-09       Impact factor: 1.978

6.  Conformational transitions and redox potential shifts of cytochrome P450 induced by immobilization.

Authors:  Smilja Todorovic; Christiane Jung; Peter Hildebrandt; Daniel H Murgida
Journal:  J Biol Inorg Chem       Date:  2005-12-03       Impact factor: 3.358

7.  Structural basis of substrate conversion in a new aromatic peroxygenase: cytochrome P450 functionality with benefits.

Authors:  Klaus Piontek; Eric Strittmatter; René Ullrich; Glenn Gröbe; Marek J Pecyna; Martin Kluge; Katrin Scheibner; Martin Hofrichter; Dietmar A Plattner
Journal:  J Biol Chem       Date:  2013-10-14       Impact factor: 5.157

8.  Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.

Authors:  Abhinav Nath; Cristina Fernández; Jed N Lampe; William M Atkins
Journal:  Arch Biochem Biophys       Date:  2008-03-25       Impact factor: 4.013

9.  Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors.

Authors:  Zhuo Cheng; Zhiying He; Yongchao Cai; Cheng Zhang; Gongbo Fu; Hengyu Li; Wen Sun; Changcheng Liu; Xiuliang Cui; Beifang Ning; Daimin Xiang; Tengfei Zhou; Xiaofeng Li; Weifen Xie; Hongyang Wang; Jin Ding
Journal:  Cell Res       Date:  2018-12-18       Impact factor: 25.617

10.  Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries.

Authors:  Zhi-Gang Zhang; Yan Liu; F Peter Guengerich; Johannes H Matse; Jun Chen; Zhong-Liu Wu
Journal:  J Biotechnol       Date:  2008-10-15       Impact factor: 3.307

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