Literature DB >> 12113811

Synthesis and anti-influenza evaluation of polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en derivatives.

Takeshi Honda1, Shuku Yoshida, Masami Arai, Takeshi Masuda, Makoto Yamashita.   

Abstract

We synthesized polyvalent sialidase inhibitors bearing 4-guanidino-Neu5Ac2en analogues on the polyglutamic acid back bone, via a spacer of alkyl ether at the C-7 position. These multivalent conjugates 9 and 10 showed enhancement of antiviral activity against infuenza A virus and more potent efficacy in vivo relative to a monomeric sialidase inhibitor.

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Year:  2002        PMID： 12113811     DOI： 10.1016/s0960-894x(02)00330-x

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

1.  Synthesis of potent inhibitors of anthrax toxin based on poly-L-glutamic acid.

Authors:  Amit Joshi; Arundhati Saraph; Vincent Poon; Jeremy Mogridge; Ravi S Kane
Journal:  Bioconjug Chem       Date:  2006 Sep-Oct       Impact factor: 4.774

2.  Polyvalent side chain peptide-synthetic polymer conjugates as HIV-1 entry inhibitors.

Authors:  Maarten Danial; Michael J Root; Harm-Anton Klok
Journal:  Biomacromolecules       Date:  2012-04-27       Impact factor: 6.988

3.  Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen.

Authors:  Simon J F Macdonald; Keith G Watson; Rachel Cameron; David K Chalmers; Derek A Demaine; Rob J Fenton; David Gower; J Nicole Hamblin; Stephanie Hamilton; Graham J Hart; Graham G A Inglis; Betty Jin; Haydn T Jones; Darryl B McConnell; Andy M Mason; Van Nguyen; Ian J Owens; Nigel Parry; Phillip A Reece; Stephen E Shanahan; Donna Smith; Wen-Yang Wu; Simon P Tucker
Journal:  Antimicrob Agents Chemother       Date:  2004-12       Impact factor: 5.191

4.  Bifunctional polymeric inhibitors of human influenza A viruses.

Authors:  Jayanta Haldar; Luis Alvarez de Cienfuegos; Terrence M Tumpey; Larisa V Gubareva; Jianzhu Chen; Alexander M Klibanov
Journal:  Pharm Res       Date:  2009-12-15       Impact factor: 4.200

5.  A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

Authors:  Masahiko Hayakawa; Narihiro Toda; Nancy Carrillo; Natalie J Thornburg; James E Crowe; Carlos F Barbas
Journal:  Chembiochem       Date:  2012-09-10       Impact factor: 3.164

6.  Synthesis of Homopolymers and Copolymers Containing an Active Ester of Acrylic Acid by RAFT: Scaffolds for Controlling Polyvalent Ligand Display.

Authors:  Kunal V Gujraty; Mallinamadugu J Yanjarappa; Arundhati Saraph; Amit Joshi; Jeremy Mogridge; Ravi S Kane
Journal:  J Polym Sci A Polym Chem       Date:  2008-09-25       Impact factor: 2.702

Review 7.  Polymeric drugs: Advances in the development of pharmacologically active polymers.

Authors:  Jing Li; Fei Yu; Yi Chen; David Oupický
Journal:  J Control Release       Date:  2015-09-26       Impact factor: 9.776

8.  Solution phase conformation and proteolytic stability of amide-linked neuraminic acid analogues.

Authors:  Jonel P Saludes; Travis Q Gregar; I Abrrey Monreal; Brandan M Cook; Lieza M Danan-Leon; Jacquelyn Gervay-Hague
Journal:  Biopolymers       Date:  2013-10       Impact factor: 2.505

9.  Zanamivir conjugated to poly-L-glutamine is much more active against influenza viruses in mice and ferrets than the drug itself.

Authors:  Alisha K Weight; Jessica A Belser; Terrence M Tumpey; Jianzhu Chen; Alexander M Klibanov
Journal:  Pharm Res       Date:  2013-09-25       Impact factor: 4.200

Review 10.  Antiviral strategies against influenza virus: towards new therapeutic approaches.

Authors:  Arianna Loregian; Beatrice Mercorelli; Giulio Nannetti; Chiara Compagnin; Giorgio Palù
Journal:  Cell Mol Life Sci       Date:  2014-04-04       Impact factor: 9.261
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