OBJECTIVES: To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. STUDY DESIGN: Eligible infants (n = 131) <2 years of age requiring open heart surgery were recruited prospectively. Subjects were assessed during surgery and again 12 to 18 months later with standardized developmental assessments and formal neurologic examinations. RESULTS: Mean age at follow-up testing was 19.1 +/- 6.6 months. Assessments indicated that 41% had abnormal neurologic examinations. Gross and/or fine motor delays were documented in 42%, and 23% demonstrated global developmental delay. Univariate and multiple regression models identified the following factors increasing the risk for persistent developmental deficits: preoperative and acute postoperative neurodevelopmental status and microcephaly, type of heart lesion, length of deep hypothermic circulatory arrest, age at surgery, and days in the intensive care unit (P <.05). CONCLUSIONS: Children with congenital heart defects commonly have ongoing neurologic, motor, and developmental deficits well after surgical correction. The cause is multifactorial and includes brain injury before, during, and after heart surgery.
OBJECTIVES: To determine the prevalence of persistent developmental impairments in children with congenital heart defects and to identify factors that enhance risk for an adverse outcome. STUDY DESIGN: Eligible infants (n = 131) <2 years of age requiring open heart surgery were recruited prospectively. Subjects were assessed during surgery and again 12 to 18 months later with standardized developmental assessments and formal neurologic examinations. RESULTS: Mean age at follow-up testing was 19.1 +/- 6.6 months. Assessments indicated that 41% had abnormal neurologic examinations. Gross and/or fine motor delays were documented in 42%, and 23% demonstrated global developmental delay. Univariate and multiple regression models identified the following factors increasing the risk for persistent developmental deficits: preoperative and acute postoperative neurodevelopmental status and microcephaly, type of heart lesion, length of deep hypothermic circulatory arrest, age at surgery, and days in the intensive care unit (P <.05). CONCLUSIONS:Children with congenital heart defects commonly have ongoing neurologic, motor, and developmental deficits well after surgical correction. The cause is multifactorial and includes brain injury before, during, and after heart surgery.
Authors: Mathieu Dehaes; Henry H Cheng; Erin M Buckley; Pei-Yi Lin; Silvina Ferradal; Kathryn Williams; Rutvi Vyas; Katherine Hagan; Daniel Wigmore; Erica McDavitt; Janet S Soul; Maria Angela Franceschini; Jane W Newburger; P Ellen Grant Journal: Biomed Opt Express Date: 2015-11-09 Impact factor: 3.732
Authors: Catherine Limperopoulos; Wayne Tworetzky; Doff B McElhinney; Jane W Newburger; David W Brown; Richard L Robertson; Nicolas Guizard; Ellen McGrath; Judith Geva; David Annese; Carolyn Dunbar-Masterson; Bethany Trainor; Peter C Laussen; Adré J du Plessis Journal: Circulation Date: 2009-12-21 Impact factor: 29.690
Authors: Michael G Gaies; Monica Langer; Jamin Alexander; Garry M Steil; Janice Ware; David Wypij; Peter C Laussen; Jane W Newburger; Caren S Goldberg; Frank A Pigula; Avinash C Shukla; Christopher P Duggan; Michael S D Agus Journal: Pediatr Crit Care Med Date: 2013-02 Impact factor: 3.624
Authors: Richard G Ohye; J William Gaynor; Nancy S Ghanayem; Caren S Goldberg; Peter C Laussen; Peter C Frommelt; Jane W Newburger; Gail D Pearson; Sarah Tabbutt; Gil Wernovsky; Lisa M Wruck; Andrew M Atz; Steve D Colan; James Jaggers; Brian W McCrindle; Ashwin Prakash; Michael D Puchalski; Lynn A Sleeper; Mario P Stylianou; Lynn Mahony Journal: J Thorac Cardiovasc Surg Date: 2008-05-19 Impact factor: 5.209
Authors: M Rosario Porcayo-Mercado; Gloria A Otero-Ojeda; F Bernardo Pliego-Rivero; Dalia M Aguirre-Pérez; Josefina Ricardo-Garcell Journal: J Clin Psychol Med Settings Date: 2013-03