Gil Wernovsky1, Daniel J Licht. 1. 1Department of Pediatrics, Section of Cardiology, Florida International University, Wertheim College of Medicine, Nicklaus Children's Hospital, Miami, FL. 2Department of Pediatrics, Section of Cardiology, Perelman School of Medicine, University of Pennsylvania, Children's Hospital of Philadelphia Philadelphia, PA.
Abstract
OBJECTIVES: The objectives of this review are to discuss the scope of neurologic injuries in newborns with congenital heart disease, the mechanisms of injury, including prenatal, pre-, intra-, and postoperative factors, neurodevelopmental outcomes, and therapeutic strategies for the timely intervention and prevention of neurologic injury. DATA SOURCE: MEDLINE and PubMed. CONCLUSION: At the current time, important research is underway to 1) better understand the developing brain in the fetus with complex congenital heart disease, 2) to identify modifiable risk factors in the operating room and ICU to maximize long-term neurodevelopmental outcomes, and 3) develop strategies to improve family psychosocial health, childhood development, and health-related quality of life following hospital discharge. Crucial in this effort is the identification of an early postoperative surrogate variable with good predictive validity for long-term outcomes. If an appropriate surrogate variable for long-term outcomes can be identified, and measured relatively early after surgical intervention for complex congenital heart disease, reliable clinical trials can be undertaken to improve upon current outcomes.
OBJECTIVES: The objectives of this review are to discuss the scope of neurologic injuries in newborns with congenital heart disease, the mechanisms of injury, including prenatal, pre-, intra-, and postoperative factors, neurodevelopmental outcomes, and therapeutic strategies for the timely intervention and prevention of neurologic injury. DATA SOURCE: MEDLINE and PubMed. CONCLUSION: At the current time, important research is underway to 1) better understand the developing brain in the fetus with complex congenital heart disease, 2) to identify modifiable risk factors in the operating room and ICU to maximize long-term neurodevelopmental outcomes, and 3) develop strategies to improve family psychosocial health, childhood development, and health-related quality of life following hospital discharge. Crucial in this effort is the identification of an early postoperative surrogate variable with good predictive validity for long-term outcomes. If an appropriate surrogate variable for long-term outcomes can be identified, and measured relatively early after surgical intervention for complex congenital heart disease, reliable clinical trials can be undertaken to improve upon current outcomes.
Authors: Daniel Seung Kim; Jerry H Kim; Amber A Burt; David R Crosslin; Nancy Burnham; Donna M McDonald-McGinn; Elaine H Zackai; Susan C Nicolson; Thomas L Spray; Ian B Stanaway; Deborah A Nickerson; Mark W Russell; Hakon Hakonarson; J William Gaynor; Gail P Jarvik Journal: Ann Thorac Surg Date: 2014-05-06 Impact factor: 4.330
Authors: Marilyn C Morris; Richard F Ittenbach; Rodolfo I Godinez; Joel D Portnoy; Sarah Tabbutt; Brian D Hanna; Timothy M Hoffman; J William Gaynor; James T Connelly; Mark A Helfaer; Thomas L Spray; Gil Wernovsky Journal: Crit Care Med Date: 2004-04 Impact factor: 7.598
Authors: Jane W Newburger; David Wypij; David C Bellinger; Adre J du Plessis; Karl C K Kuban; Leonard A Rappaport; Daniel Almirall; David L Wessel; Richard A Jonas; Gil Wernovsky Journal: J Pediatr Date: 2003-07 Impact factor: 4.406
Authors: Gonzalo Garcia Guerra; Charlene M T Robertson; Gwen Y Alton; Ari R Joffe; Dominic A Cave; Farzana Yasmin; Irina A Dinu; Dianne E Creighton; David B Ross; Ivan M Rebeyka Journal: Paediatr Anaesth Date: 2013-09-19 Impact factor: 2.556
Authors: Milan Prsa; Liqun Sun; Joshua van Amerom; Shi-Joon Yoo; Lars Grosse-Wortmann; Edgar Jaeggi; Christopher Macgowan; Mike Seed Journal: Circ Cardiovasc Imaging Date: 2014-05-29 Impact factor: 7.792
Authors: Jennifer M Lynch; Erin M Buckley; Peter J Schwab; Ann L McCarthy; Madeline E Winters; David R Busch; Rui Xiao; Donna A Goff; Susan C Nicolson; Lisa M Montenegro; Stephanie Fuller; J William Gaynor; Thomas L Spray; Arjun G Yodh; Maryam Y Naim; Daniel J Licht Journal: J Thorac Cardiovasc Surg Date: 2014-06-27 Impact factor: 5.209
Authors: Sara K Pasquali; David M Shahian; Sean M O'Brien; Marshall L Jacobs; J William Gaynor; Jennifer C Romano; Michael G Gaies; Kevin D Hill; John E Mayer; Jeffrey P Jacobs Journal: Ann Thorac Surg Date: 2018-09-15 Impact factor: 4.330
Authors: Elizabeth C Ciociola; Karan R Kumar; Kanecia O Zimmerman; Elizabeth J Thompson; Melissa Harward; Laura N Sullivan; Joseph W Turek; Christoph P Hornik Journal: Cardiol Young Date: 2019-11-27 Impact factor: 1.093
Authors: Amy J Lisanti; Abigail C Demianczyk; Andrew Costarino; Maria G Vogiatzi; Rebecca Hoffman; Ryan Quinn; Jesse L Chittams; Barbara Medoff-Cooper Journal: J Obstet Gynecol Neonatal Nurs Date: 2020-11-09
Authors: Erica Sood; Amy Jo Lisanti; Sarah E Woolf-King; Jo Wray; Nadine Kasparian; Emily Jackson; Mary R Gregory; Keila N Lopez; Bradley S Marino; Trent Neely; Amy Randall; Sinai C Zyblewski; Cheryl L Brosig Journal: Cardiol Young Date: 2021-06-04 Impact factor: 1.093