Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Barrier passage and protein dynamics in enzymatically catalyzed reactions.

Literature DB >> 12084050

Barrier passage and protein dynamics in enzymatically catalyzed reactions.

Dimitri Antoniou¹, Stavros Caratzoulas, C Kalyanaraman, Joshua S Mincer, Steven D Schwartz.

Abstract

This review describes studies of particular enzymatically catalyzed reactions to investigate the possibility that catalysis is mediated by protein dynamics. That is, evolution has crafted the protein backbone of the enzyme to direct vibrations in such a fashion to speed reaction. The review presents the theoretical approach we have used to investigate this problem, but it is designed for the nonspecialist. The results show that in alcohol dehydrogenase, dynamic protein motion is in fact strongly coupled to chemical reaction in such a way as to promote catalysis. This result is in concert with both experimental data and interpretations for this and other enzyme systems studied in the laboratories of the two other investigators who have published reviews in this issue.

Mesh：

Substances：
Enzymes

Year: 2002 PMID： 12084050 DOI： 10.1046/j.1432-1033.2002.03021.x

Source DB: PubMed Journal: Eur J Biochem ISSN： 0014-2956

Keyword Cloud
Cited

41 in total

1. How an enzyme surmounts the activation energy barrier.

Authors: Richard L Schowen
Journal: Proc Natl Acad Sci U S A Date: 2003-10-06 Impact factor: 11.205

2. The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase.

Authors: Lin Wang; Nina M Goodey; Stephen J Benkovic; Amnon Kohen
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2006-08-29 Impact factor: 6.237

3. Protein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic control.

Authors: J R E T Pineda; S D Schwartz
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2006-08-29 Impact factor: 6.237

Review 4. Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions.

Authors: Jingzhi Pu; Jiali Gao; Donald G Truhlar
Journal: Chem Rev Date: 2006-08 Impact factor: 60.622

5. Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase.

Authors: Jingzhi Pu; Shuhua Ma; Jiali Gao; Donald G Truhlar
Journal: J Phys Chem B Date: 2005-05-12 Impact factor: 2.991

Review 10. Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.

Authors: Karunesh Arora; Charles L Brooks
Journal: Top Curr Chem Date: 2013

Barrier passage and protein dynamics in enzymatically catalyzed reactions.

1. How an enzyme surmounts the activation energy barrier.

2. The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase.

3. Protein dynamics and catalysis: the problems of transition state theory and the subtlety of dynamic control.

Review 4. Multidimensional tunneling, recrossing, and the transmission coefficient for enzymatic reactions.

5. Small temperature dependence of the kinetic isotope effect for the hydride transfer reaction catalyzed by Escherichia coli dihydrofolate reductase.

6. Effects of a distal mutation on active site chemistry.

7. Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase.

8. Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase.

9. Anticorrelated motions as a driving force in enzyme catalysis: the dehydrogenase reaction.

Review 10. Multiple intermediates, diverse conformations, and cooperative conformational changes underlie the catalytic hydride transfer reaction of dihydrofolate reductase.