V C Petersen1, K J Baxter, S B Love, N A Shepherd. 1. Department of Histopathology and Cranfield Postgraduate Medical School in Gloucestershire, Gloucestershire Royal Hospital, Great Western Road, Gloucester GL1 3NN, UK.
Abstract
BACKGROUND AND AIMS: There is a need for objective easily determined pathological prognostic parameters in Dukes' B colon carcinoma to allow selection of such patients for further treatment as the role of adjuvant chemotherapy for these patients remains unclear. This study was initiated to assess the influence of pathological factors on prognosis in an unselected prospective series of Dukes' B colonic cancer. METHODS: The Gloucester Colorectal Cancer study, established in 1988, recruited more than 1000 cases. Meticulous pathological assessment of the 268 Dukes' B colonic cancer resections in this series included evaluation of all pathological factors that could influence staging and prognosis. All patients entered a comprehensive follow up system. RESULTS: Four pathologically determined factors--peritoneal involvement, venous spread (both submucosal and extramural), spread to involve a surgical margin, and perforation through the tumour-were independent prognostic factors in multivariate analysis. Combining these four factors into a simple cumulative scoring system generated clinically useful prognostic groups. CONCLUSIONS: The cumulative prognostic index allows apportionment of patients with Dukes' B colon cancer into defined prognostic groups, which in turn could allow more objective selection of patients for adjuvant therapy, especially as part of clinical trials.
BACKGROUND AND AIMS: There is a need for objective easily determined pathological prognostic parameters in Dukes' B colon carcinoma to allow selection of such patients for further treatment as the role of adjuvant chemotherapy for these patients remains unclear. This study was initiated to assess the influence of pathological factors on prognosis in an unselected prospective series of Dukes' B colonic cancer. METHODS: The Gloucester Colorectal Cancer study, established in 1988, recruited more than 1000 cases. Meticulous pathological assessment of the 268 Dukes' B colonic cancer resections in this series included evaluation of all pathological factors that could influence staging and prognosis. All patients entered a comprehensive follow up system. RESULTS: Four pathologically determined factors--peritoneal involvement, venous spread (both submucosal and extramural), spread to involve a surgical margin, and perforation through the tumour-were independent prognostic factors in multivariate analysis. Combining these four factors into a simple cumulative scoring system generated clinically useful prognostic groups. CONCLUSIONS: The cumulative prognostic index allows apportionment of patients with Dukes' B colon cancer into defined prognostic groups, which in turn could allow more objective selection of patients for adjuvant therapy, especially as part of clinical trials.
Authors: M J O'Connell; J A Mailliard; M J Kahn; J S Macdonald; D G Haller; R J Mayer; H S Wieand Journal: J Clin Oncol Date: 1997-01 Impact factor: 44.544
Authors: I J Adam; M O Mohamdee; I G Martin; N Scott; P J Finan; D Johnston; M F Dixon; P Quirke Journal: Lancet Date: 1994-09-10 Impact factor: 79.321
Authors: W Scheithauer; G V Kornek; A Marczell; J Karner; G Salem; R Greiner; D Burger; F Stöger; J Ritschel; E Kovats; H M Vischer; B Schneeweiss; D Depisch Journal: Br J Cancer Date: 1998-04 Impact factor: 7.640
Authors: Raymond Oliphant; David Mansouri; Gary A Nicholson; Donald C McMillan; Paul G Horgan; David S Morrison Journal: Int J Colorectal Dis Date: 2014-03-22 Impact factor: 2.571
Authors: Young Taik Oh; Myeong Jin Kim; Joon Seok Lim; Joo Hee Kim; Kang Young Lee; Nam Kyu Kim; Won Ho Kim; Ki Whang Kim Journal: Korean J Radiol Date: 2005 Jan-Mar Impact factor: 3.500