BACKGROUND: Cancer registries recording all cases diagnosed in a well defined population represent the only way to assess real changes in the management of colon cancer at the population level. AIMS: To determine trends over a 23 year period in treatment, stage at diagnosis, and prognosis of colon cancer in the Côte-d'Or region, France. PATIENTS: A total of 3389 patients with colon cancer diagnosed between 1976 and 1998. METHODS: Time trends in clinical presentation, surgical treatment, chemotherapy treatment, stage at diagnosis, postoperative mortality, and survival were studied. A non-conditional logistic regression was performed to obtain an odds ratio for each period adjusted for the other variables. To estimate the independent effect of the period on prognosis, a relative survival analysis was performed. RESULTS: Between 1976 and 1991, the resection rate increased from 69.3% to 91.9% and then remained stable. This increase was particularly marked in the older age group (56.4% to 90.5%). The proportion of stage III patients treated with adjuvant chemotherapy rose from 4.1% for the 1989-1990 period to 45.7% for the 1997-1998 period. Over the 23 years of the study the proportion of stage I and II patients increased from 39.6% to 56.6%, associated with a corresponding decrease in the proportion of patients with advanced stages. Postoperative mortality decreased from 19.5% to 7.3%. This led to an improvement in five year relative survival (from 33.0% for the 1976-1979 period to 55.3% for the 1992-1995 period). CONCLUSIONS: Advances in the management of colon cancer have resulted in improving the prognosis of this disease. However, progress is still possible, particularly in the older age group.
BACKGROUND: Cancer registries recording all cases diagnosed in a well defined population represent the only way to assess real changes in the management of colon cancer at the population level. AIMS: To determine trends over a 23 year period in treatment, stage at diagnosis, and prognosis of colon cancer in the Côte-d'Or region, France. PATIENTS: A total of 3389 patients with colon cancer diagnosed between 1976 and 1998. METHODS: Time trends in clinical presentation, surgical treatment, chemotherapy treatment, stage at diagnosis, postoperative mortality, and survival were studied. A non-conditional logistic regression was performed to obtain an odds ratio for each period adjusted for the other variables. To estimate the independent effect of the period on prognosis, a relative survival analysis was performed. RESULTS: Between 1976 and 1991, the resection rate increased from 69.3% to 91.9% and then remained stable. This increase was particularly marked in the older age group (56.4% to 90.5%). The proportion of stage III patients treated with adjuvant chemotherapy rose from 4.1% for the 1989-1990 period to 45.7% for the 1997-1998 period. Over the 23 years of the study the proportion of stage I and II patients increased from 39.6% to 56.6%, associated with a corresponding decrease in the proportion of patients with advanced stages. Postoperative mortality decreased from 19.5% to 7.3%. This led to an improvement in five year relative survival (from 33.0% for the 1976-1979 period to 55.3% for the 1992-1995 period). CONCLUSIONS: Advances in the management of colon cancer have resulted in improving the prognosis of this disease. However, progress is still possible, particularly in the older age group.
Authors: M Sant; R Capocaccia; A Verdecchia; G Gatta; A Micheli; A Mariotto; T Hakulinen; F Berrino Journal: Int J Cancer Date: 1995-09-27 Impact factor: 7.396
Authors: G Gatta; R Capocaccia; M Sant; C M Bell; J W Coebergh; R A Damhuis; J Faivre; C Martinez-Garcia; J Pawlega; M Ponz de Leon; D Pottier; N Raverdy; E M Williams; F Berrino Journal: Gut Date: 2000-10 Impact factor: 23.059
Authors: C G Moertel; T R Fleming; J S Macdonald; D G Haller; J A Laurie; P J Goodman; J S Ungerleider; W A Emerson; D C Tormey; J H Glick Journal: N Engl J Med Date: 1990-02-08 Impact factor: 91.245
Authors: C Lamberti; S Lundin; M Bogdanow; C Pagenstecher; N Friedrichs; R Büttner; T Sauerbruch Journal: Int J Colorectal Dis Date: 2006-05-25 Impact factor: 2.571
Authors: Katelin A Mirkin; Christopher S Hollenbeak; Ali Mohamed; Yuxia Jia; Wafik S El-Deiry; Evangelos Messaris Journal: Cancer Biol Ther Date: 2017-05-05 Impact factor: 4.742
Authors: T B Leal; T Holden; L Cavalcante; G O Allen; J R Schumacher; M A Smith; J M Weiss; H B Neuman; N K LoConte Journal: Ann Hematol Oncol Date: 2014
Authors: M Ponz de Leon; G Rossi; C di Gregorio; C De Gaetani; F Rossi; G Ponti; L Pecone; M Pedroni; L Roncucci; A Pezzi; P Benatti Journal: Intern Emerg Med Date: 2007-11-29 Impact factor: 3.397