| Literature DB >> 12069986 |
Wei-Hua Zhao1, Zhi-Qing Hu, Yukihiko Hara, Tadakatsu Shimamura.
Abstract
The combination of epigallocatechin gallate (EGCg, a main constituent of tea catechins) with penicillin showed synergism against 21 clinical isolates of penicillinase-producing Staphylococcus aureus. Besides binding directly to peptidoglycan, the inhibition of penicillinase activity by EGCg is responsible for the synergism. EGCg inhibited the penicillinase activity in a dose-dependent fashion, with a 50% inhibitory concentration of 10 microg/ml.Entities:
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Year: 2002 PMID: 12069986 PMCID: PMC127279 DOI: 10.1128/AAC.46.7.2266-2268.2002
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191