Literature DB >> 12069986

Inhibition of penicillinase by epigallocatechin gallate resulting in restoration of antibacterial activity of penicillin against penicillinase-producing Staphylococcus aureus.

Wei-Hua Zhao1, Zhi-Qing Hu, Yukihiko Hara, Tadakatsu Shimamura.   

Abstract

The combination of epigallocatechin gallate (EGCg, a main constituent of tea catechins) with penicillin showed synergism against 21 clinical isolates of penicillinase-producing Staphylococcus aureus. Besides binding directly to peptidoglycan, the inhibition of penicillinase activity by EGCg is responsible for the synergism. EGCg inhibited the penicillinase activity in a dose-dependent fashion, with a 50% inhibitory concentration of 10 microg/ml.

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Year:  2002        PMID: 12069986      PMCID: PMC127279          DOI: 10.1128/AAC.46.7.2266-2268.2002

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  19 in total

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Review 4.  Beta-lactamases.

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5.  Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus.

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Journal:  Antimicrob Agents Chemother       Date:  2002-02       Impact factor: 5.191

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8.  Epigallocatechin gallate synergy with ampicillin/sulbactam against 28 clinical isolates of methicillin-resistant Staphylococcus aureus.

Authors:  Z Q Hu; W H Zhao; Y Hara; T Shimamura
Journal:  J Antimicrob Chemother       Date:  2001-09       Impact factor: 5.790

9.  Transferable imipenem resistance in Pseudomonas aeruginosa.

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Journal:  Antimicrob Agents Chemother       Date:  1991-01       Impact factor: 5.191

10.  Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate.

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  38 in total

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Review 6.  Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea.

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7.  Antibacterial effects of green tea polyphenols on clinical isolates of methicillin-resistant Staphylococcus aureus.

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8.  Epigallocatechin-gallate enhances the activity of tetracycline in staphylococci by inhibiting its efflux from bacterial cells.

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9.  Antimicrobial effect and membrane-active mechanism of tea polyphenols against Serratia marcescens.

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10.  Green tea catechins quench the fluorescence of bacteria-conjugated Alexa fluor dyes.

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