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Literature DB >> 11796378

Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus.

Zhi-Qing Hu¹, Wei-Hua Zhao, Nozomi Asano, Yoshiyuki Yoda, Yukihiko Hara, Tadakatsu Shimamura.

Abstract

Combinations of carbapenems and epigallocatechin gallate (EGCg; a main constituent of tea catechins) showed potent synergy against 24 clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). MICs of imipenem in the presence of EGCg at 3.125, 6.25, 12.5, and 25 microg/ml, were restored to the susceptible breakpoint (< or =4 microg/ml) for 8, 38, 46, and 75% of the MRSA isolates, respectively. Similar results were also observed for combinations of panipenem or meropenem and EGCg. Therefore, the combinations may be worthy of further evaluation in vivo against MRSA infection.

Entities: Chemical Disease Species

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Year: 2002 PMID： 11796378 PMCID： PMC127028 DOI： 10.1128/AAC.46.2.558-560.2002

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

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Journal: Planta Med Date: 2000-06 Impact factor: 3.352

4. Reduced susceptibility of Staphylococcus aureus to vancomycin--Japan, 1996.

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5. Comparison of susceptibility testing methods with mecA gene analysis for determining oxacillin (methicillin) resistance in clinical isolates of Staphylococcus aureus and coagulase-negative Staphylococcus spp.

Authors: P Kohner; J Uhl; C Kolbert; D Persing; F Cockerill
Journal: J Clin Microbiol Date: 1999-09 Impact factor: 5.948

6. The effect of a component of tea (Camellia sinensis) on methicillin resistance, PBP2' synthesis, and beta-lactamase production in Staphylococcus aureus.

Authors: T S Yam; J M Hamilton-Miller; S Shah
Journal: J Antimicrob Chemother Date: 1998-08 Impact factor: 5.790

7. Analysis of (-)-epigallocatechin gallate in human serum obtained after ingesting green tea.

Authors: T Unno; K Kondo; H Itakura; T Takeo
Journal: Biosci Biotechnol Biochem Date: 1996-12 Impact factor: 2.043

8. Epigallocatechin gallate synergy with ampicillin/sulbactam against 28 clinical isolates of methicillin-resistant Staphylococcus aureus.

Authors: Z Q Hu; W H Zhao; Y Hara; T Shimamura
Journal: J Antimicrob Chemother Date: 2001-09 Impact factor: 5.790

9. Absorption and distribution of tea catechin, (-)-epigallocatechin-3-gallate, in the rat.

Authors: K Nakagawa; T Miyazawa
Journal: J Nutr Sci Vitaminol (Tokyo) Date: 1997-12 Impact factor: 2.000

10. Analysis of plasma and urinary tea polyphenols in human subjects.

Authors: M J Lee; Z Y Wang; H Li; L Chen; Y Sun; S Gobbo; D A Balentine; C S Yang
Journal: Cancer Epidemiol Biomarkers Prev Date: 1995-06 Impact factor: 4.254

33 in total

Review 1. Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

Authors: David Brown
Journal: Nat Rev Drug Discov Date: 2015-10-23 Impact factor: 84.694

2. Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa.

Authors: Maksum Radji; Rafael Adi Agustama; Berna Elya; Conny Riana Tjampakasari
Journal: Asian Pac J Trop Biomed Date: 2013-08

10. Epigallocatechin gallate induces upregulation of the two-component VraSR system by evoking a cell wall stress response in Staphylococcus aureus.

Authors: Oren Levinger; Tamar Bikels-Goshen; Elad Landau; Merav Fichman; Roni Shapira
Journal: Appl Environ Microbiol Date: 2012-08-31 Impact factor: 4.792

Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus aureus.

1. World-wide antibiotic resistance in methicillin-resistant Staphylococcus aureus.

2. Comparison of techniques for measurement of in vitro antibiotic synergism.

3. Oral absorption and bioavailability of tea catechins.

4. Reduced susceptibility of Staphylococcus aureus to vancomycin--Japan, 1996.

5. Comparison of susceptibility testing methods with mecA gene analysis for determining oxacillin (methicillin) resistance in clinical isolates of Staphylococcus aureus and coagulase-negative Staphylococcus spp.

6. The effect of a component of tea (Camellia sinensis) on methicillin resistance, PBP2' synthesis, and beta-lactamase production in Staphylococcus aureus.

7. Analysis of (-)-epigallocatechin gallate in human serum obtained after ingesting green tea.

8. Epigallocatechin gallate synergy with ampicillin/sulbactam against 28 clinical isolates of methicillin-resistant Staphylococcus aureus.

9. Absorption and distribution of tea catechin, (-)-epigallocatechin-3-gallate, in the rat.

10. Analysis of plasma and urinary tea polyphenols in human subjects.

Review 1. Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

2. Antimicrobial activity of green tea extract against isolates of methicillin-resistant Staphylococcus aureus and multi-drug resistant Pseudomonas aeruginosa.

3. Alkyl gallates, intensifiers of beta-lactam susceptibility in methicillin-resistant Staphylococcus aureus.

4. Laser light combined with a photosensitizer may eliminate methicillin-resistant strains of Staphylococcus aureus.

5. Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophilia.

6. Duckweed (Lemna minor) as a model plant system for the study of human microbial pathogenesis.

Review 7. Anti-infective properties of epigallocatechin-3-gallate (EGCG), a component of green tea.

8. Antibacterial effects of green tea polyphenols on clinical isolates of methicillin-resistant Staphylococcus aureus.

9. Effect of ethanolic extract of Ecballium elaterium against Staphylococcus aureus and Candida albicans.

10. Epigallocatechin gallate induces upregulation of the two-component VraSR system by evoking a cell wall stress response in Staphylococcus aureus.