Literature DB >> 12067591

Apolipoproteins and aging: emerging mechanisms.

Jonathan D Smith1.   

Abstract

One of the goals of modern medicine is to foster successful aging. In order to age successfully, one must accomplish two things: first, survive; and second, survive with good health and a sharp mind. In this discussion of apolipoproteins and aging, the focus will be on apolipoprotein E (apoE), a protein with three common isoforms, which has a large impact on longevity and successful aging. One variant of apoE (E4) is associated with increased risk for heart disease, stroke and Alzheimer's disease (AD). In addition, some of the potential mechanisms for the observed effects of apoE on aging will be discussed.

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Year:  2002        PMID： 12067591     DOI： 10.1016/s1568-1637(02)00005-3

Source DB:  PubMed          Journal:  Ageing Res Rev        ISSN： 1568-1637            Impact factor:   10.895


  37 in total

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4.  ApoE and pulse pressure interactively influence level and change in the aging of episodic memory: Protective effects among ε2 carriers.

Authors:  G Peggy McFall; Sandra A Wiebe; David Vergote; David Westaway; Jack Jhamandas; Lars Bäckman; Roger A Dixon
Journal:  Neuropsychology       Date:  2014-12-01       Impact factor: 3.295

Review 5.  Genetics and functional imaging: effects of APOE, BDNF, COMT, and KIBRA in aging.

Authors:  Goran Papenberg; Alireza Salami; Jonas Persson; Ulman Lindenberger; Lars Bäckman
Journal:  Neuropsychol Rev       Date:  2015-02-10       Impact factor: 7.444

6.  Molecular cloning and characterization of the promoter region of the porcine apolipoprotein E gene.

Authors:  Jihan Xia; Bingjun Hu; Yulian Mu; Leilei Xin; Shulin Yang; Kui Li
Journal:  Mol Biol Rep       Date:  2014-01-24       Impact factor: 2.316

7.  Apolipoprotein-E genotype and human immunodeficiency virus-associated neurocognitive disorder: the modulating effects of older age and disease severity.

Authors:  Stella E Panos; Charles H Hinkin; Elyse J Singer; April D Thames; Sapna M Patel; Janet S Sinsheimer; A C Del Re; Benjamin B Gelman; Susan Morgello; David J Moore; Andrew J Levine
Journal:  Neurobehav HIV Med       Date:  2013-06-19

8.  Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.

Authors:  Rong Lin; Yunxia Zhang; Dongjing Yan; Xiaoping Liao; Gu Gong; Junjie Hu; Yunxin Fu; Wangwei Cai
Journal:  J Hum Genet       Date:  2015-12-10       Impact factor: 3.172

9.  Selection on alleles affecting human longevity and late-life disease: the example of apolipoprotein E.

Authors:  Fotios Drenos; Thomas B L Kirkwood
Journal:  PLoS One       Date:  2010-04-02       Impact factor: 3.240

10.  Variability in APOE genotype status in human-derived cell lines: a cause for concern in cell culture studies?

Authors:  Sebastian Schaffer; Vanessa Y M Lam; Insa M A Ernst; Patricia Huebbe; Gerald Rimbach; Barry Halliwell
Journal:  Genes Nutr       Date:  2013-12-03       Impact factor: 5.523
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