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Literature DB >> 25666727

Genetics and functional imaging: effects of APOE, BDNF, COMT, and KIBRA in aging.

Goran Papenberg¹, Alireza Salami, Jonas Persson, Ulman Lindenberger, Lars Bäckman.

Abstract

Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from age-comparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.

Entities: Gene

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Year: 2015 PMID： 25666727 DOI： 10.1007/s11065-015-9279-8

Source DB: PubMed Journal: Neuropsychol Rev ISSN： 1040-7308 Impact factor: 7.444

142 in total

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20 in total

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