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Literature DB >> 12065549

Treponema denticola is resistant to human beta-defensins.

Catherine A Brissette¹, Sheila A Lukehart.

Abstract

Spirochetes, including Treponema denticola, are implicated in the pathogenesis of periodontal disease. Because T. denticola lacks lipopolysaccharides that serve as targets for human beta-defensin (h beta D) binding, we postulated that T. denticola would resist killing by h beta D. We showed that T. denticola is resistant to h beta D-1 and -2. Protease inhibitors did not enhance killing of T. denticola by h beta D-2, suggesting that degradation of h beta D-2 by treponemal proteases is not a major factor in T. denticola resistance.

Entities: Chemical Disease Species

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Year: 2002 PMID： 12065549 PMCID： PMC128080 DOI： 10.1128/IAI.70.7.3982-3984.2002

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

27 in total

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14 in total

Review 1. Host defense peptides in the oral cavity and the lung: similarities and differences.

Authors: G Diamond; N Beckloff; L K Ryan
Journal: J Dent Res Date: 2008-10 Impact factor: 6.116

2. The antibacterial activity of LL-37 against Treponema denticola is dentilisin protease independent and facilitated by the major outer sheath protein virulence factor.

Authors: Graciela Rosen; Michael N Sela; Gilad Bachrach
Journal: Infect Immun Date: 2011-12-19 Impact factor: 3.441

3. Mechanisms of decreased susceptibility to beta-defensins by Treponema denticola.

Authors: Catherine A Brissette; Sheila A Lukehart
Journal: Infect Immun Date: 2007-02-26 Impact factor: 3.441

Review 4. Beta-defensins: what are they really doing in the oral cavity?

Authors: G Diamond; Lk Ryan
Journal: Oral Dis Date: 2011-02-18 Impact factor: 3.511

5. Treponema denticola does not induce production of common innate immune mediators from primary gingival epithelial cells.

Authors: C A Brissette; T-T T Pham; S R Coats; R P Darveau; S A Lukehart
Journal: Oral Microbiol Immunol Date: 2008-12

6. Novel hairpin-shaped primer assay to study the association of the -44 single-nucleotide polymorphism of the DEFB1 gene with early-onset periodontal disease.

Authors: Michele Boniotto; Manzour Hernando Hazbón; William James Jordan; Greig Patrick Lennon; Joyce Eskdale; David Alland; Grant Gallagher
Journal: Clin Diagn Lab Immunol Date: 2004-07