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Literature DB >> 12062096

PI 3-kinases and PTEN: how opposites chemoattract.

Abstract

Phosphatidylinositol lipids, such as PI(4,5)P2 and PI(3,4,5)P3, are key mediators in diverse intracellular signaling pathways. Two recent reports examine how the metabolism of these lipids by phosphatidylinositol 3-kinases and the PTEN 3-phosphoinositide phosphatase may coordinate G protein coupled signaling pathways during eukaryotic chemotaxis.

Entities: Chemical Gene

Mesh：

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Year: 2002 PMID： 12062096 DOI： 10.1016/s0092-8674(02)00765-1

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

45 in total

1. A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium.

Authors: Binggang Sun; Richard A Firtel
Journal: Mol Biol Cell Date: 2003-04 Impact factor: 4.138

2. The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium.

Authors: Angelika A Noegel; Rosemarie Blau-Wasser; Hameeda Sultana; Rolf Müller; Lars Israel; Michael Schleicher; Hitesh Patel; Cornelis J Weijer
Journal: Mol Biol Cell Date: 2003-10-31 Impact factor: 4.138

3. Eukaryotic chemotaxis.

Authors: Wouter-Jan Rappel; William F Loomis
Journal: Wiley Interdiscip Rev Syst Biol Med Date: 2009 Jul-Aug

4. α-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts.

Authors: Min Jeong Kim; Stanley C Froehner; Marvin E Adams; Hye Sun Kim
Journal: Exp Cell Res Date: 2011-10-06 Impact factor: 3.905

5. Bias in the gradient-sensing response of chemotactic cells.

Authors: Ron Skupsky; Colin McCann; Ralph Nossal; Wolfgang Losert
Journal: J Theor Biol Date: 2007-03-06 Impact factor: 2.691

6. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.

Authors: Matthias Niedermeier; Bryan T Hennessy; Zachary A Knight; Marina Henneberg; Jianhua Hu; Antonina V Kurtova; William G Wierda; Michael J Keating; Kevan M Shokat; Jan A Burger
Journal: Blood Date: 2009-03-24 Impact factor: 22.113

PI 3-kinases and PTEN: how opposites chemoattract.

1. A regulator of G protein signaling-containing kinase is important for chemotaxis and multicellular development in dictyostelium.

2. The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium.

3. Eukaryotic chemotaxis.

4. α-Syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts.

5. Bias in the gradient-sensing response of chemotactic cells.

6. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach.

Review 7. Cell motility in cancer invasion and metastasis: insights from simple model organisms.

8. From Physics to Pharmacology?

9. miR-19 is a key oncogenic component of mir-17-92.

10. A role for the juxtamembrane domain of beta-dystroglycan in agrin-induced acetylcholine receptor clustering.