Literature DB >> 12055110

Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment.

Lars Ohberg1, H Alfredson.   

Abstract

BACKGROUND: The mechanism that causes pain in chronic Achilles tendinosis is not known. However, high resolution colour Doppler ultrasound has shown that neovascularisation may be involved.
OBJECTIVE: To investigate if sclerosing the neovessels would affect the level of tendon pain.
METHODS: The effect of colour Doppler ultrasound guided injection of a sclerosing agent, polidocanol, against neovessels was studied in 10 patients (seven men and three women, mean age 55 years) with painful chronic mid-portion Achilles tendinosis.
RESULTS: Eight patients were satisfied with the results of treatment. There was significantly reduced pain during activity (reported on a visual analogue scale (VAS)) and no remaining neovascularisation after an average of two injections. Two patients were not satisfied, and neovascularisation remained. At the six month follow up, the same eight patients remained satisfied and could perform Achilles tendon loading activities as desired. Their VAS score had decreased from 74 before treatment to 8 (p<0.01).
CONCLUSIONS: Sclerosing neovessels appears to be an effective treatment for painful chronic Achilles tendinosis, suggesting that neovessels play a key part in causing chronic tendon pain.

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Year:  2002        PMID: 12055110      PMCID: PMC1724500          DOI: 10.1136/bjsm.36.3.173

Source DB:  PubMed          Journal:  Br J Sports Med        ISSN: 0306-3674            Impact factor:   13.800


  13 in total

1.  Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin.

Authors:  K M Khan; J L Cook; N Maffulli; P Kannus
Journal:  Br J Sports Med       Date:  2000-04       Impact factor: 13.800

2.  Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment?

Authors:  H Alfredson; S Forsgren; K Thorsen; M Fahlström; H Johansson; R Lorentzon
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2001       Impact factor: 4.342

3.  In situ microdialysis in tendon tissue: high levels of glutamate, but not prostaglandin E2 in chronic Achilles tendon pain.

Authors:  H Alfredson; K Thorsen; R Lorentzon
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  1999       Impact factor: 4.342

4.  Tendon pathology in long-standing achillodynia. Biopsy findings in 40 patients.

Authors:  T Movin; A Gad; F P Reinholt; C Rolf
Journal:  Acta Orthop Scand       Date:  1997-04

5.  Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation.

Authors:  L Ohberg; R Lorentzon; H Alfredson
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2001-07       Impact factor: 4.342

6.  Superior short-term results with eccentric calf muscle training compared to concentric training in a randomized prospective multicenter study on patients with chronic Achilles tendinosis.

Authors:  N Mafi; R Lorentzon; H Alfredson
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2001       Impact factor: 4.342

7.  Sclerotherapy for treatment of hemangiomas.

Authors:  H Winter; E Dräger; W Sterry
Journal:  Dermatol Surg       Date:  2000-02       Impact factor: 3.398

8.  Indications for the sclerosing agent polidocanol (aetoxisclerol dexo, aethoxisklerol kreussler)

Authors:  J J Guex
Journal:  J Dermatol Surg Oncol       Date:  1993-10

9.  The Australian polidocanol (aethoxysklerol) study. Results at 2 years.

Authors:  P Conrad; G M Malouf; M C Stacey
Journal:  Dermatol Surg       Date:  1995-04       Impact factor: 3.398

10.  Chronic Achilles tendinopathy. A survey of surgical and histopathologic findings.

Authors:  M Aström; A Rausing
Journal:  Clin Orthop Relat Res       Date:  1995-07       Impact factor: 4.176

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  86 in total

Review 1.  Treatment of midportion Achilles tendinopathy: an evidence-based overview.

Authors:  Ruben Zwiers; Johannes I Wiegerinck; C Niek van Dijk
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2014-11-01       Impact factor: 4.342

2.  Tendon injury and repair after core biopsies in chronic Achilles tendinosis evaluated by serial magnetic resonance imaging.

Authors:  A Shalabi; L Svensson; M Kristoffersen-Wiberg; P Aspelin; T Movin
Journal:  Br J Sports Med       Date:  2004-10       Impact factor: 13.800

3.  Correlation between computerised findings and Newman's scaling on vascularity using power Doppler ultrasonography imaging and its predictive value in patients with plantar fasciitis.

Authors:  H Chen; H M Ho; M Ying; S N Fu
Journal:  Br J Radiol       Date:  2011-12-13       Impact factor: 3.039

Review 4.  Ultrasound-guided treatments for chronic Achilles tendinopathy: an update and current status.

Authors:  Nevin T Wijesekera; Ne Siang Chew; Justin C Lee; Adam W Mitchell; James D Calder; Jeremiah C Healy
Journal:  Skeletal Radiol       Date:  2010-02-01       Impact factor: 2.199

Review 5.  Ultrasound-guided intervention in the ankle and foot.

Authors:  Eleni E Drakonaki; Gina M Allen; Roland Watura
Journal:  Br J Radiol       Date:  2015-11-05       Impact factor: 3.039

6.  High reproducibility of patellar tendon vascularity assessed by colour Doppler ultrasonography: a reliable measurement tool for quantifying tendon pathology.

Authors:  J L Cook; R Ptazsnik; Z S Kiss; P Malliaras; M E Morris; J De Luca
Journal:  Br J Sports Med       Date:  2005-10       Impact factor: 13.800

7.  Healing of donor site in bone-tendon-bone ACL reconstruction accelerated with plasma rich in growth factors: a randomized clinical trial.

Authors:  Roberto Seijas; Marta Rius; Oscar Ares; Montserrat García-Balletbó; Iván Serra; Ramón Cugat
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2013-11-27       Impact factor: 4.342

8.  Treatment of midportion Achilles tendinosis: similar clinical results with US and CD-guided surgery outside the tendon and sclerosing polidocanol injections.

Authors:  Håkan Alfredson; Lars Ohberg; Ewa Zeisig; Ronny Lorentzon
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2007-09-18       Impact factor: 4.342

9.  Neovascularisation in chronic painful patellar tendinosis--promising results after sclerosing neovessels outside the tendon challenge the need for surgery.

Authors:  Håkan Alfredson; Lars Ohberg
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2004-11-26       Impact factor: 4.342

10.  The long-term clinical and MRI results following eccentric calf muscle training in chronic Achilles tendinosis.

Authors:  Anna Gärdin; Tomas Movin; Leif Svensson; Adel Shalabi
Journal:  Skeletal Radiol       Date:  2009-09-23       Impact factor: 2.199

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