Literature DB >> 15756611

Neovascularisation in chronic painful patellar tendinosis--promising results after sclerosing neovessels outside the tendon challenge the need for surgery.

Håkan Alfredson1, Lars Ohberg.   

Abstract

Sclerosing injections targeting neovascularisation have been demonstrated to give promising clinical results in patients with chronic painful Achilles tendinosis. In this study, fifteen elite or recreational athletes (12 men and three women) with the diagnosis patellar tendinosis/Jumper's knee in 15 patellar tendons were included. All the patients had a long duration of pain symptoms (mean = 23 months) from the patellar tendon, and ultra-sonography + colour doppler examination showed structural tendon changes with hypo-echoic areas and a neovascularisation, corresponding to the painful area. The patients were treated with ultrasound and colour doppler-guided injections of the sclerosing substance Polidocanol, targeting the area with neovascularisation. At follow-up (mean = 6 months) after a mean amount of three treatments, there was a good clinical result in 12/15 tendons. The patients were back to their previous (before injury) sport activity level, and the amount of pain recorded on a VAS-scale had decreased significantly (VAS from 81 to 10). Our findings indicate that treatment with sclerosing injections, targeting the area with neovessels in patellar tendinosis, has the potential to cure the pain in the tendons and also allow the patients to go back to full patellar-tendon loading activity.

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Year:  2004        PMID: 15756611     DOI: 10.1007/s00167-004-0549-x

Source DB:  PubMed          Journal:  Knee Surg Sports Traumatol Arthrosc        ISSN: 0942-2056            Impact factor:   4.342


  23 in total

1.  Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin.

Authors:  K M Khan; J L Cook; N Maffulli; P Kannus
Journal:  Br J Sports Med       Date:  2000-04       Impact factor: 13.800

2.  Ultrasound-guided percutaneous longitudinal tenotomy for the management of patellar tendinopathy.

Authors:  V Testa; G Capasso; N Maffulli; G Bifulco
Journal:  Med Sci Sports Exerc       Date:  1999-11       Impact factor: 5.411

3.  In vivo microdialysis and immunohistochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper's knee.

Authors:  H Alfredson; S Forsgren; K Thorsen; R Lorentzon
Journal:  J Orthop Res       Date:  2001-09       Impact factor: 3.494

4.  Open and arthroscopic patellar tenotomy for chronic patellar tendinopathy. A retrospective outcome study. Victorian Institute of Sport Tendon Study Group.

Authors:  B D Coleman; K M Khan; Z S Kiss; J Bartlett; D A Young; J D Wark
Journal:  Am J Sports Med       Date:  2000 Mar-Apr       Impact factor: 6.202

5.  Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies. Victorian Institute of Sport Tendon Study Group.

Authors:  B D Coleman; K M Khan; N Maffulli; J L Cook; J D Wark
Journal:  Scand J Med Sci Sports       Date:  2000-02       Impact factor: 4.221

6.  Patellar tendon ultrasonography and jumper's knee in female basketball players: a longitudinal study.

Authors:  K M Khan; J L Cook; Z S Kiss; P J Visentini; M W Fehrmann; P R Harcourt; B W Tress; J D Wark
Journal:  Clin J Sport Med       Date:  1997-07       Impact factor: 3.638

7.  A cross sectional study of 100 athletes with jumper's knee managed conservatively and surgically. The Victorian Institute of Sport Tendon Study Group.

Authors:  J L Cook; K M Khan; P R Harcourt; M Grant; D A Young; S F Bonar
Journal:  Br J Sports Med       Date:  1997-12       Impact factor: 13.800

8.  Indications for the sclerosing agent polidocanol (aetoxisclerol dexo, aethoxisklerol kreussler)

Authors:  J J Guex
Journal:  J Dermatol Surg Oncol       Date:  1993-10

9.  Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment.

Authors:  Lars Ohberg; H Alfredson
Journal:  Br J Sports Med       Date:  2002-06       Impact factor: 13.800

10.  The Australian polidocanol (aethoxysklerol) study. Results at 2 years.

Authors:  P Conrad; G M Malouf; M C Stacey
Journal:  Dermatol Surg       Date:  1995-04       Impact factor: 3.398

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  52 in total

1.  Correlation between computerised findings and Newman's scaling on vascularity using power Doppler ultrasonography imaging and its predictive value in patients with plantar fasciitis.

Authors:  H Chen; H M Ho; M Ying; S N Fu
Journal:  Br J Radiol       Date:  2011-12-13       Impact factor: 3.039

Review 2.  The pain of tendinopathy: physiological or pathophysiological?

Authors:  Ebonie Rio; Lorimer Moseley; Craig Purdam; Tom Samiric; Dawson Kidgell; Alan J Pearce; Shapour Jaberzadeh; Jill Cook
Journal:  Sports Med       Date:  2014-01       Impact factor: 11.136

3.  Increased intratendinous vascularity in the early period after sclerosing injection treatment in Achilles tendinosis : a healing response?

Authors:  Håkan Alfredson; Lars Ohberg
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2006-03-15       Impact factor: 4.342

Review 4.  Ultrasound- and Doppler-guided arthroscopic shaving to treat Jumper's knee: a technical note.

Authors:  Lotta Willberg; Kerstin Sunding; Magnus Forssblad; Håkan Alfredson
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2007-08-25       Impact factor: 4.342

5.  The Value of Visa-Score and Colour Flow Imaging in the Follow-Up of Non-Athletes Operated for Jumpers Knee.

Authors:  Eirik S Salvesen; Ketil J Holen
Journal:  J Sports Sci Med       Date:  2016-12-01       Impact factor: 2.988

6.  Ultrasound guided electrocoagulation in patients with chronic non-insertional Achilles tendinopathy: a pilot study.

Authors:  M Ilum Boesen; S Torp-Pedersen; M Juhl Koenig; R Christensen; H Langberg; P Hölmich; M Bachmann Nielsen; H Bliddal
Journal:  Br J Sports Med       Date:  2006-06-28       Impact factor: 13.800

7.  Synergistic activity of platelet rich plasma and high volume image guided injection for patellar tendinopathy.

Authors:  Michele Abate; Luigi Di Carlo; Sandra Verna; Patrizia Di Gregorio; Cosima Schiavone; Vincenzo Salini
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2018-03-31       Impact factor: 4.342

8.  The prevalence of neovascularity in patients clinically diagnosed with rotator cuff tendinopathy.

Authors:  Jeremy S Lewis; Syed A Raza; James Pilcher; Christine Heron; Jan D Poloniecki
Journal:  BMC Musculoskelet Disord       Date:  2009-12-21       Impact factor: 2.362

9.  Endoscopic treatment of chronic mid-portion Achilles tendinopathy: novel technique with short-term results.

Authors:  Hajo Thermann; Ioannis S Benetos; Christina Panelli; Iosif Gavriilidis; Sven Feil
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  2009-03-14       Impact factor: 4.342

Review 10.  Overuse injuries in female athletes.

Authors:  Alan Ivković; Miljenko Franić; Ivan Bojanić; Marko Pećina
Journal:  Croat Med J       Date:  2007-12       Impact factor: 1.351

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