| Literature DB >> 12042777 |
Carl D Novina1, Michael F Murray, Derek M Dykxhoorn, Paul J Beresford, Jonathan Riess, Sang-Kyung Lee, Ronald G Collman, Judy Lieberman, Premlata Shankar, Phillip A Sharp.
Abstract
RNA interference silences gene expression through short interfering 21 23-mer double-strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here we report that siRNAs inhibit virus production by targeting the mRNAs for either the HIV-1 cellular receptor CD4, the viral structural Gag protein or green fluorescence protein substituted for the Nef regulatory protein. siRNAs effectively inhibit pre- and/or post-integration infection events in the HIV-1 life cycle. Thus, siRNAs may have potential for therapeutic intervention in HIV-1 and other viral infections.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12042777 DOI： 10.1038/nm725
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440