Literature DB >> 14657237

RNA interference and mRNA silencing, 2004: how far will they reach?

Thoru Pederson1.   

Abstract

The discoveries of RNA interference and RNA-mediated posttranscriptional gene silencing have opened an unanticipated new window on the regulation of gene expression as well as a facile and highly effective tool for knocking down gene expression in many organisms and cells. In addition, RNA interference and RNA silencing may conceivably be exploited for human therapeutics sometime in the future, possibly bringing greater clinical impact than have the so far disappointing antisense endeavors. This essay summarizes recent developments and offers some personalized perspectives, with emphasis on what we do not yet know.

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Year:  2003        PMID： 14657237      PMCID： PMC329193          DOI： 10.1091/mbc.e03-10-0726

Source DB:  PubMed          Journal:  Mol Biol Cell        ISSN： 1059-1524            Impact factor:   4.138


  47 in total

1.  Identification of novel genes coding for small expressed RNAs.

Authors:  M Lagos-Quintana; R Rauhut; W Lendeckel; T Tuschl
Journal:  Science       Date:  2001-10-26       Impact factor: 47.728

2.  MicroRNAs: deviants no longer.

Authors:  Amy E Pasquinelli
Journal:  Trends Genet       Date:  2002-04       Impact factor: 11.639

Review 3.  MicroRNAs: hidden in the genome.

Authors:  Eric G Moss
Journal:  Curr Biol       Date:  2002-02-19       Impact factor: 10.834

4.  Ancient pathways programmed by small RNAs.

Authors:  Phillip D Zamore
Journal:  Science       Date:  2002-05-17       Impact factor: 47.728

5.  siRNA-directed inhibition of HIV-1 infection.

Authors:  Carl D Novina; Michael F Murray; Derek M Dykxhoorn; Paul J Beresford; Jonathan Riess; Sang-Kyung Lee; Ronald G Collman; Judy Lieberman; Premlata Shankar; Phillip A Sharp
Journal:  Nat Med       Date:  2002-06-03       Impact factor: 53.440

6.  RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E.

Authors:  Jason R Kennerdell; Shinji Yamaguchi; Richard W Carthew
Journal:  Genes Dev       Date:  2002-08-01       Impact factor: 11.361

7.  miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs.

Authors:  Zissimos Mourelatos; Josée Dostie; Sergey Paushkin; Anup Sharma; Bernard Charroux; Linda Abel; Juri Rappsilber; Matthias Mann; Gideon Dreyfuss
Journal:  Genes Dev       Date:  2002-03-15       Impact factor: 11.361

8.  An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans.

Authors:  N C Lau; L P Lim; E G Weinstein; D P Bartel
Journal:  Science       Date:  2001-10-26       Impact factor: 47.728

9.  Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference.

Authors:  P Svoboda; P Stein; H Hayashi; R M Schultz
Journal:  Development       Date:  2000-10       Impact factor: 6.868

10.  Modulation of HIV-1 replication by RNA interference.

Authors:  Jean-Marc Jacque; Karine Triques; Mario Stevenson
Journal:  Nature       Date:  2002-06-26       Impact factor: 69.504
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  2 in total

1.  Therapeutic potential of a combination of two gene-specific small interfering RNAs against clinical strains of Acanthamoeba.

Authors:  Jacob Lorenzo-Morales; Carmen M Martín-Navarro; Atteneri López-Arencibia; María A Santana-Morales; Raquel N Afonso-Lehmann; Sutherland K Maciver; Basilio Valladares; Enrique Martínez-Carretero
Journal:  Antimicrob Agents Chemother       Date:  2010-09-20       Impact factor: 5.191

Review 2.  New strategies in drug discovery.

Authors:  Eliot H Ohlstein; Anthony G Johnson; John D Elliott; Anne M Romanic
Journal:  Methods Mol Biol       Date:  2006
  2 in total

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