Literature DB >> 12040264

What is the best sample for determining the early postmortem period by on-the-spot flow cytometry analysis?

Nunzio Di Nunno1, Fulvio Costantinides, Stephen J Cina, Clara Rizzardi, Cosimo Di Nunno, Mauro Melato.   

Abstract

The level of degradation of DNA as a means for determining the time of death has been proposed as a valid adjunct to the classic thanatochronologic methods. The twofold aim of this work was to determine which organ might reveal both a correlation between the percentage of degradation of the DNA and the time lapse since death, and would be easiest to sample and yield the most reproducible results even in technically unfavorable situations such as on-the-spot investigations at the scene of death. A comparison of the spleen, blood, and liver showed that hepatic tissue best meets these specific needs because it shows a virtually linear correlation between the time elapsed since death and the level of degradation of the DNA, and it can easily be sampled at the scene of death by use of a common biopsy needle.

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Year:  2002        PMID: 12040264     DOI: 10.1097/00000433-200206000-00013

Source DB:  PubMed          Journal:  Am J Forensic Med Pathol        ISSN: 0195-7910            Impact factor:   0.921


  5 in total

1.  Determination of the early time of death by computerized image analysis of DNA degradation: which is the best quantitative indicator of DNA degradation?

Authors:  Lijiang Liu; Xiji Shu; Liang Ren; Hongyan Zhou; Yan Li; Wei Liu; Cheng Zhu; Liang Liu
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2007-08

2.  Biospecimen reporting for improved study quality (BRISQ).

Authors:  Helen M Moore; Andrea B Kelly; Scott D Jewell; Lisa M McShane; Douglas P Clark; Renata Greenspan; Daniel F Hayes; Pierre Hainaut; Paula Kim; Elizabeth Mansfield; Olga Potapova; Peter Riegman; Yaffa Rubinstein; Edward Seijo; Stella Somiari; Peter Watson; Heinz-Ulrich Weier; Claire Zhu; Jim Vaught
Journal:  J Proteome Res       Date:  2011-06-21       Impact factor: 4.466

3.  Biospecimen Reporting for Improved Study Quality.

Authors:  Helen M Moore; Andrea Kelly; Scott D Jewell; Lisa M McShane; Douglas P Clark; Renata Greenspan; Pierre Hainaut; Daniel F Hayes; Paula Kim; Elizabeth Mansfield; Olga Potapova; Peter Riegman; Yaffa Rubinstein; Edward Seijo; Stella Somiari; Peter Watson; Heinz-Ulrich Weier; Claire Zhu; Jim Vaught
Journal:  Biopreserv Biobank       Date:  2011-04       Impact factor: 2.300

4.  DNA degradation within mouse brain and dental pulp cells 72 hours postmortem.

Authors:  Jilong Zheng; Xiaona Li; Di Shan; Han Zhang; Dawei Guan
Journal:  Neural Regen Res       Date:  2012-02-05       Impact factor: 5.135

5.  The Role of DNA Degradation in the Estimation of Post-Mortem Interval: A Systematic Review of the Current Literature.

Authors:  Pamela Tozzo; Salvatore Scrivano; Matteo Sanavio; Luciana Caenazzo
Journal:  Int J Mol Sci       Date:  2020-05-17       Impact factor: 5.923

  5 in total

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