Literature DB >> 12029057

Formation of dTDP-rhamnose is essential for growth of mycobacteria.

Yufang Ma1, Fei Pan, Michael McNeil.   

Abstract

It was determined that the dTDP-rhamnose synthesis gene, rmlD, could be inactivated in Mycobacterium smegmatis only in the presence of a rescue plasmid carrying functional rmlD. Hence, dTDP-rhamnose biosynthesis is essential for the growth of mycobacteria and the targeting of dTDP-rhamnose synthesis for new tuberculosis drugs is supported.

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Year:  2002        PMID： 12029057      PMCID： PMC135104          DOI： 10.1128/JB.184.12.3392-3395.2002

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  22 in total

1.  Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar Typhimurium.

Authors:  M F Giraud; H J McMiken; G A Leonard; P Messner; C Whitfield; J H Naismith
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1999-12

2.  The crystal structure of dTDP-D-Glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium, the second enzyme in the dTDP-l-rhamnose pathway.

Authors:  S T Allard; M F Giraud; C Whitfield; M Graninger; P Messner; J H Naismith
Journal:  J Mol Biol       Date:  2001-03-16       Impact factor: 5.469

3.  Drug targeting Mycobacterium tuberculosis cell wall synthesis: genetics of dTDP-rhamnose synthetic enzymes and development of a microtiter plate-based screen for inhibitors of conversion of dTDP-glucose to dTDP-rhamnose.

Authors:  Y Ma; R J Stern; M S Scherman; V D Vissa; W Yan; V C Jones; F Zhang; S G Franzblau; W H Lewis; M R McNeil
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

4.  Use of biotinylated DNA probes in colony hybridization.

Authors:  M J Haas; D J Fleming
Journal:  Nucleic Acids Res       Date:  1986-05-12       Impact factor: 16.971

5.  The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase.

Authors:  A Melo; W H Elliott; L Glaser
Journal:  J Biol Chem       Date:  1968-04-10       Impact factor: 5.157

6.  Biosynthesis of thymidine diphosphate L-rhamnose in Escherichia coli K-12.

Authors:  H Nikaido; K Nikaido; A M Rapin
Journal:  Biochim Biophys Acta       Date:  1965-12-16

7.  Cell wall core galactofuran synthesis is essential for growth of mycobacteria.

Authors:  F Pan; M Jackson; Y Ma; M McNeil
Journal:  J Bacteriol       Date:  2001-07       Impact factor: 3.490

8.  Phosphatidylinositol is an essential phospholipid of mycobacteria.

Authors:  M Jackson; D C Crick; P J Brennan
Journal:  J Biol Chem       Date:  2000-09-29       Impact factor: 5.157

9.  Construction and use of low-copy number T7 expression vectors for purification of problem proteins: purification of mycobacterium tuberculosis RmlD and pseudomonas aeruginosa LasI and RhlI proteins, and functional analysis of purified RhlI.

Authors:  T T Hoang; Y Ma; R J Stern; M R McNeil; H P Schweizer
Journal:  Gene       Date:  1999-09-17       Impact factor: 3.688

10.  Biological mechanisms involved in the formation of deoxysugars. I. Preparation of thymidine diphosphate glucose labeled specifically in carbon 3.

Authors:  O Gabriel; G Ashwell
Journal:  J Biol Chem       Date:  1965-11       Impact factor: 5.157
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  25 in total

1.  Identification of an L-rhamnose synthetic pathway in two nucleocytoplasmic large DNA viruses.

Authors:  Madhu Parakkottil Chothi; Garry A Duncan; Andrea Armirotti; Chantal Abergel; James R Gurnon; James L Van Etten; Cinzia Bernardi; Gianluca Damonte; Michela Tonetti
Journal:  J Virol       Date:  2010-06-10       Impact factor: 5.103

Review 2.  Targeting the formation of the cell wall core of M. tuberculosis.

Authors:  Clifton E Barry; Dean C Crick; Michael R McNeil
Journal:  Infect Disord Drug Targets       Date:  2007-06

Review 3.  The Mycobacterial Cell Wall--Peptidoglycan and Arabinogalactan.

Authors:  Luke J Alderwick; James Harrison; Georgina S Lloyd; Helen L Birch
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4.  Advances in the treatment of pulmonary tuberculosis.

Authors:  Xia Zhang; Jing Guo
Journal:  J Thorac Dis       Date:  2012-12       Impact factor: 2.895

5.  Novel multiplex real-time PCR diagnostic assay for identification and differentiation of Mycobacterium tuberculosis, Mycobacterium canettii, and Mycobacterium tuberculosis complex strains.

Authors:  Kate Reddington; Justin O'Grady; Siobhan Dorai-Raj; Majella Maher; Dick van Soolingen; Thomas Barry
Journal:  J Clin Microbiol       Date:  2010-12-01       Impact factor: 5.948

6.  Biosynthesis of UDP-4-keto-6-deoxyglucose and UDP-rhamnose in pathogenic fungi Magnaporthe grisea and Botryotinia fuckeliana.

Authors:  Viviana Martinez; Miles Ingwers; James Smith; John Glushka; Ting Yang; Maor Bar-Peled
Journal:  J Biol Chem       Date:  2011-11-18       Impact factor: 5.157

7.  Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-d-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC).

Authors:  Sharmila Sivendran; Victoria Jones; Dianqing Sun; Yi Wang; Anna E Grzegorzewicz; Michael S Scherman; Andrew D Napper; J Andrew McCammon; Richard E Lee; Scott L Diamond; Michael McNeil
Journal:  Bioorg Med Chem       Date:  2009-11-20       Impact factor: 3.641

8.  Computational evaluation of phytocompounds for combating drug resistant tuberculosis by multi-targeted therapy.

Authors:  Sudharsana Sundarrajan; Sajitha Lulu; Mohanapriya Arumugam
Journal:  J Mol Model       Date:  2015-09-01       Impact factor: 1.810

9.  Expression, essentiality, and a microtiter plate assay for mycobacterial GlmU, the bifunctional glucosamine-1-phosphate acetyltransferase and N-acetylglucosamine-1-phosphate uridyltransferase.

Authors:  Wenli Zhang; Victoria C Jones; Michael S Scherman; Sebabrata Mahapatra; Dean Crick; Suresh Bhamidi; Yi Xin; Michael R McNeil; Yufang Ma
Journal:  Int J Biochem Cell Biol       Date:  2008-05-15       Impact factor: 5.085

Review 10.  The cell envelope glycoconjugates of Mycobacterium tuberculosis.

Authors:  Shiva Kumar Angala; Juan Manuel Belardinelli; Emilie Huc-Claustre; William H Wheat; Mary Jackson
Journal:  Crit Rev Biochem Mol Biol       Date:  2014-06-10       Impact factor: 8.250
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