Literature DB >> 7432551

Specific 3H-imipramine binding in human platelets. Influence of age and sex.

S Z Langer, M S Briley, R Raisman, J F Henry, P L Morselli.   

Abstract

Human platelets have been shown to possess high-affinity binding sites for 3H-imipramine. These binding sites have a similar affinity and drug specificity to those already described in rat brain. The platelets from healthy volunteers show no difference in 3H-imipramine binding between the sexes but there is a decrease in maximal 3H-imipramine binding with increasing age of the donor.

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Year:  1980        PMID: 7432551     DOI: 10.1007/bf00505732

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN: 0028-1298            Impact factor:   3.000


  28 in total

1.  The relationship between decreased 5-hydroxyindole metabolism and mental defect in phenylketonuria.

Authors:  C M PARE; M SANDLER; R S STACEY
Journal:  Arch Dis Child       Date:  1959-10       Impact factor: 3.791

2.  beta-Adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity.

Authors:  L H Greenberg; B Weiss
Journal:  Science       Date:  1978-07-07       Impact factor: 47.728

3.  Reduced cyclic AMP production in the blood platelets from schizophrenic patients.

Authors:  M S Kafka; D P van Kammen; W E Bunney
Journal:  Am J Psychiatry       Date:  1979-05       Impact factor: 18.112

4.  Reduced monoamine oxidase activity in blood platelets from schizophrenic patients.

Authors:  D L Murphy; R J Wyatt
Journal:  Nature       Date:  1972-07-28       Impact factor: 49.962

5.  Human platelets possess high-affinity binding sites for 3H-imipramine.

Authors:  M S Briley; R Raisman; S Z Langer
Journal:  Eur J Pharmacol       Date:  1979-10-01       Impact factor: 4.432

6.  Paranoia and platelet MAO in normals and nonschizophrenic psychiatric groups.

Authors:  R J Haier; D L Murphy; M S Buchsbaum
Journal:  Am J Psychiatry       Date:  1979-03       Impact factor: 18.112

7.  High-affinity 3H-imipramine binding in rat cerebral cortex.

Authors:  R Raisman; M Briley; S Z Langer
Journal:  Eur J Pharmacol       Date:  1979-03-01       Impact factor: 4.432

8.  Specific tricyclic antidepressant binding sites in rat brain.

Authors:  R Raisman; M Briley; S Z Langer
Journal:  Nature       Date:  1979-09-13       Impact factor: 49.962

9.  Studies on human blood platelets in affective disorder.

Authors:  M Scott; H W Reading; J B Loudon
Journal:  Psychopharmacology (Berl)       Date:  1979-01-31       Impact factor: 4.530

10.  Tritiated imipramine binding sites are decreased in platelets of untreated depressed patients.

Authors:  M S Briley; S Z Langer; R Raisman; D Sechter; E Zarifian
Journal:  Science       Date:  1980-07-11       Impact factor: 47.728

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  17 in total

1.  Reduced Bmax of [3H]-imipramine binding to platelets of depressed patients free of previous medication with 5HT uptake inhibitors.

Authors:  M F Poirier; C Benkelfat; H Loo; D Sechter; E Zarifian; A M Galzin; S Z Langer
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

Review 2.  Antidepressants and serotonergic neurotransmission: an integrative review.

Authors:  P Willner
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

3.  Simultaneous measurement of epinephrine-induced platelet aggregation in 14 plasma samples.

Authors:  K Nelson; S Heintz; S Ulrich; R Kirsten
Journal:  Eur J Clin Pharmacol       Date:  1986       Impact factor: 2.953

Review 4.  Studies on the serotonin transporter in platelets.

Authors:  S Z Langer; A M Galzin
Journal:  Experientia       Date:  1988-02-15

5.  Platelet 3H-imipramine binding and steroid hormones serum concentrations during the menstrual cycle.

Authors:  M F Poirier; C Benkelfat; A M Galzin; S Z Langer
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

6.  Factors affecting serotonin uptake into human platelets.

Authors:  E E Codd; T W McAllister; R F Walker
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

7.  Proceedings of the British Pharmacological Society. University of Leicester, 6th-8th July, 1983. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1983-09       Impact factor: 8.739

8.  3H-imipramine binding in platelets: influence of varying proportions of intact platelets in membrane preparations on binding.

Authors:  W Friedl; P Propping; B Weck
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

9.  Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects.

Authors:  D S Charney; S W Woods; W K Goodman; G R Heninger
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

10.  Short-term lithium administration to healthy volunteers produces long-lasting pronounced changes in platelet serotonin uptake but not imipramine binding.

Authors:  M F Poirier; A M Galzin; C Pimoule; H Schoemaker; K H Le Quan Bui; P Meyer; C Gay; H Loo; S Z Langer
Journal:  Psychopharmacology (Berl)       Date:  1988       Impact factor: 4.530

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