Literature DB >> 533310

Fate and comparative toxicity of metallothioneins with differing Cd/Zn ratios in rat kidney.

K T Suzuki, S Takenaka, K Kubota.   

Abstract

Metallothioneins with differing Cd/Zn ratios were prepared in vitro from rat liver zinc-thionein by replacing zinc with cadmium and were injected intraperitoneally to female rats. The distribution of cadmium, zinc, and copper in the kidney supernatant fraction was determined using a Sephadex G-75 column. The distribution pattern of cadmium and zinc changed dramatically within 24 hr after the injection. The changes were explained by the degradation and re-synthesis of metallothionein in the kidneys. The necrotic changes of renal tubular lining cells were correlated to the amount of cadmium in the metallothionein but not to the amount of metallothionein (protein).

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Year:  1979        PMID： 533310     DOI： 10.1007/BF01055143

Source DB:  PubMed          Journal:  Arch Environ Contam Toxicol        ISSN： 0090-4341            Impact factor:   2.804


  19 in total

1.  Metabolism of intravenously injected cadmium-binding protein.

Authors:  M G Cherian; Z A Shaikh
Journal:  Biochem Biophys Res Commun       Date:  1975-08-04       Impact factor: 3.575

2.  Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis.

Authors:  M P Richards; R J Cousins
Journal:  Biochem Biophys Res Commun       Date:  1975-06-16       Impact factor: 3.575

3.  Metallothionein: a cadmium- and zinc-containing protein from equine renal cortex.

Authors:  J H KAGI; B L VALEE
Journal:  J Biol Chem       Date:  1960-12       Impact factor: 5.157

4.  An investigation of the role of metallothioneins in protection against the acute toxicity of the cadmium ion.

Authors:  M Webb; R D Verschoyle
Journal:  Biochem Pharmacol       Date:  1976-03-15       Impact factor: 5.858

5.  Zinc-binding protein: relationship to short term changes in zinc metabolism.

Authors:  M P Richards; R J Cousins
Journal:  Proc Soc Exp Biol Med       Date:  1976-10

6.  Human hepatic metallothioneins.

Authors:  R H Bühler; J H Kägi
Journal:  FEBS Lett       Date:  1974-02-15       Impact factor: 4.124

7.  Purification and some properties of Cd-binding protein from rat liver.

Authors:  D R Winge; K V Rajagopalan
Journal:  Arch Biochem Biophys       Date:  1972-12       Impact factor: 4.013

8.  Studies on the toxicity and metabolism of cadmium-thionein.

Authors:  M Webb; A T Etienne
Journal:  Biochem Pharmacol       Date:  1977-01-01       Impact factor: 5.858

9.  Formation, circular dichroism and x-ray photoelectron spectroscopy of hepatic Zn-thionein.

Authors:  G Sokolowski; U Weser
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1975-11

10.  Accumulation and depletion of zinc in rat liver and kidney metallothionens.

Authors:  R W Chen; E J Vasey; P D Whanger
Journal:  J Nutr       Date:  1977-05       Impact factor: 4.798
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  13 in total

1.  The teratogenicity of cadmium-metallothionein in the rat.

Authors:  M Webb; D Holt; N Brown; G C Hard
Journal:  Arch Toxicol       Date:  1988       Impact factor: 5.153

2.  Gel and anion exchange chromatographic properties of copper-containing metallothioneins.

Authors:  K T Suzuki; M Yamamura
Journal:  Arch Environ Contam Toxicol       Date:  1979       Impact factor: 2.804

3.  Copper content in cadmium-exposed animal kidney metallothioneins.

Authors:  K T Suzuki
Journal:  Arch Environ Contam Toxicol       Date:  1979       Impact factor: 2.804

4.  The chronic toxicity of equine cadmium metallothionein in the rat.

Authors:  D Holt; S Sparrow; M Webb
Journal:  Arch Toxicol       Date:  1985-08       Impact factor: 5.153

5.  Autoradiographical studies on the localization of metallothionein in proximal tubular cells of the rat kidney.

Authors:  M Murakami; C Tohyama; K Sano; R Kawamura; K Kubota
Journal:  Arch Toxicol       Date:  1983-07       Impact factor: 5.153

6.  Metabolic fate of earthworm cadmium-binding proteins in rats.

Authors:  K T Suzuki; M Yamamura; T Mori
Journal:  Arch Environ Contam Toxicol       Date:  1980       Impact factor: 2.804

7.  Effect of pretreatment with cadmium/cysteine or metallothionein on accumulation of cadmium challenged with either complexes.

Authors:  K T Suzuki; T Takahara; H Watanabe; M Nishikawa; M Yamamura; M Murakami
Journal:  Arch Toxicol       Date:  1986-04       Impact factor: 5.153

8.  Structure of the metal clusters in rabbit liver metallothionein.

Authors:  J D Otvos; I M Armitage
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

9.  The accumulation and intracellular compartmentation of cadmium, lead, zinc and calcium in two earthworm species (Dendrobaena rubida and Lumbricus rubellus) living in highly contaminated soil.

Authors:  A J Morgan; B Morris
Journal:  Histochemistry       Date:  1982

10.  Native and induced rat kidney metallothioneins and their relation to cadmium toxicity.

Authors:  K T Suzuki; M Yamamura
Journal:  Arch Environ Contam Toxicol       Date:  1981       Impact factor: 2.804
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