Literature DB >> 1200978

Hemoglobin synthesis studies of a family with alpha-thalassemia trait and sickle cell trait.

J R Shaeffer, J DeSimone, L J Kleve.   

Abstract

The ratio of total globin alpha to beta chain synthesis was determined in reticulocytes isolated from the blood of the members of a black family, some of whom had sickle cell trait with low blood HbS concentrations (25-30%). The results support the hypothesis that sickle cell trait individuals with low HbS concentrations also carry a gene for alpha-thalassemia.

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Year:  1975        PMID： 1200978     DOI： 10.1007/bf00484410

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  19 in total

1.  Abnormal hemoglobins in a Brazilian Negro population.

Authors:  C V TONDO; F M SALZANO
Journal:  Am J Hum Genet       Date:  1962-12       Impact factor: 11.025

2.  Properties and inheritance of the new fast hemoglobin type found in umbilical cord blood samples of Negro babies.

Authors:  T H HUISMAN
Journal:  Clin Chim Acta       Date:  1960-09       Impact factor: 3.786

3.  Multiple inherited erythrocyte abnormalities in an American Negro family: hereditary spherocytosis, sickling and thalassemia.

Authors:  F COHEN; W W ZUELZER; J V NEEL; A R ROBINSON
Journal:  Blood       Date:  1959-07       Impact factor: 22.113

4.  Ratio of sickle-cell anemia hemoglobin to normal hemoglobin in sicklemics.

Authors:  I C WELLS; H A ITANO
Journal:  J Biol Chem       Date:  1951-01       Impact factor: 5.157

5.  Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis).

Authors:  J M Taylor; A Dozy; Y W Kan; H E Varmus; L E Lie-Injo; J Ganesan; D Todd
Journal:  Nature       Date:  1974-10-04       Impact factor: 49.962

6.  The severe form of alpha thalassaemia is caused by a haemoglobin gene deletion.

Authors:  S Ottolenghi; W G Lanyon; J Paul; R Williamson; D J Weatherall; J B Clegg; J Pritchard; S Pootrakul; W H Boon
Journal:  Nature       Date:  1974-10-04       Impact factor: 49.962

7.  Rapid turnover of newly-synthesized beta S chains in reticulocytes from individuals with sickle cell trait.

Authors:  J DeSimone; L Kleve; M A Longley; J Shaeffer
Journal:  Biochem Biophys Res Commun       Date:  1974-03-15       Impact factor: 3.575

8.  Structure and synthesis of the unstable hemoglobin Sabin (alpha 2 beta 2--91 Leu leads to pro).

Authors:  J R Shaeffer
Journal:  J Biol Chem       Date:  1973-11-10       Impact factor: 5.157

9.  Genetic determination of phenotypic variation in sickle cell trait.

Authors:  W E Nance; J Grove
Journal:  Science       Date:  1972-08-25       Impact factor: 47.728

10.  A new sickling disorder resulting from interaction of the genes for haemoglobin S and alpha-thalassaemia.

Authors:  D J Weatherall; J B Clegg; J Blankson; J R McNeil
Journal:  Br J Haematol       Date:  1969-12       Impact factor: 6.998
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  4 in total

1.  Interaction of alpha-thalassemia genes with each other and with HbC in an American black family.

Authors:  B K Walker; J Atwater; S K Ballas
Journal:  Biochem Genet       Date:  1979-12       Impact factor: 1.890

2.  Alpha-thalassemia and the production of different alpha chain variants in heterozygotes.

Authors:  A E Felice; B B Webber; T H Huisman
Journal:  Biochem Genet       Date:  1981-06       Impact factor: 1.890

3.  Genetic hemoglobin abnormalities in 2363 Cuban newborns.

Authors:  G Martínez; M E Cañizares
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132

4.  Modification of hemoglobin H disease by sickle trait.

Authors:  K K Matthay; W C Mentzer; A M Dozy; Y W Kan; D F Bainton
Journal:  J Clin Invest       Date:  1979-10       Impact factor: 14.808
  4 in total

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