Literature DB >> 5054150

Genetic determination of phenotypic variation in sickle cell trait.

W E Nance, J Grove.   

Abstract

Two genetic sources of variation influence the percentage of sickle cell hemoglobin found in heterozygotes. One factor is strongly related to the percentage of hemoglobin S in the carrier parent and appears to be determined by sickle hemoglobin isoalleles, whereas the other is related to racial background and may well be polygenic.

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Year:  1972        PMID： 5054150     DOI： 10.1126/science.177.4050.716

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Hemoglobin synthesis studies of a family with alpha-thalassemia trait and sickle cell trait.

Authors:  J R Shaeffer; J DeSimone; L J Kleve
Journal:  Biochem Genet       Date:  1975-12       Impact factor: 1.890

2.  Age trends in the prevalence of the sickle cell trait.

Authors:  D T Janerich; J H Kelly; F D Ziegler; S Selvin; I H Porter; J B Robinson; R C Herdman
Journal:  Health Serv Rep       Date:  1973-11

3.  Effects of alpha-thalassemia and sickle polymerization tendency on the urine-concentrating defect of individuals with sickle cell trait.

Authors:  A K Gupta; K A Kirchner; R Nicholson; J G Adams; A N Schechter; C T Noguchi; M H Steinberg
Journal:  J Clin Invest       Date:  1991-12       Impact factor: 14.808

4.  Genetics of hemoglobin in the deer mouse, Peromyscus maniculatus. II. Multiple alleles at regulatory loci.

Authors:  L R Snyder
Journal:  Genetics       Date:  1978-07       Impact factor: 4.562
  4 in total

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