Literature DB >> 7169216

Genetic hemoglobin abnormalities in 2363 Cuban newborns.

G Martínez, M E Cañizares.   

Abstract

A total of 2363 Cuban newborns were screened for genetic hemoglobin abnormalities; 2187 (92.56%) had a normal electrophoretic pattern. Of the 176 samples with abnormal electrophoretic patterns, 102 (4.32%) had hemoglobins A, F plus Bart's; 54 (2.29%) had hemoglobins A, F and S; 3 (0.13%) had hemoglobins A, F, S plus Bart's; 14 (0.59%) had hemoglobins A, F and C; 1 (0.04%) had hemoglobins A, F, C and Bart's. The frequency of Hb Bart's was 4.46% in AA phenotype, 5.25% in AS, and 6.67% in AC. Two newborns were found to have rare variants. A close correlation was found between the observed and expected phenotypes, which indicates the accuracy of the diagnostic methods used. The results of all hemoglobin abnormalities were entered on the infants' hospital records. In addition, these families received genetic counseling.

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Year:  1982        PMID： 7169216     DOI： 10.1007/bf00333530

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  10 in total

1.  Hemoglobin synthesis studies of a family with alpha-thalassemia trait and sickle cell trait.

Authors:  J R Shaeffer; J DeSimone; L J Kleve
Journal:  Biochem Genet       Date:  1975-12       Impact factor: 1.890

2.  Abnormal haemoglobins in the neonatal period and their relationship to thalassaemia.

Authors:  D J WEATHERALL
Journal:  Br J Haematol       Date:  1963-07       Impact factor: 6.998

3.  Cord-blood screening considerations: identification of heterozygous conditions, hemoglobin Bart's, and other hemoglobinopathies.

Authors:  E J Hicks; W P Loh; R Hamilton; R Horton
Journal:  Clin Chem       Date:  1977-09       Impact factor: 8.327

4.  Trimodality in the percentages of beta chain variants in heterozygotes: the effect of the number of active Hbalpha structural loci.

Authors:  T H Huisman
Journal:  Hemoglobin       Date:  1977       Impact factor: 0.849

5.  Genetic haemoglobin abnormalities in about 9000 Black and 7000 White newborns; haemoglobin F Dickinson (Agamma97His-Arg), a new variant.

Authors:  R G Schneider; M E Haggard; L P Gustavson; B Brimhall; R T Jones
Journal:  Br J Haematol       Date:  1974-12       Impact factor: 6.998

6.  Screening cord bloods for detection of sickle cell disease in Jamaica.

Authors:  B E Serjeant; M Forbes; L L Williams; G R Serjeant
Journal:  Clin Chem       Date:  1974-06       Impact factor: 8.327

7.  Studies on the heterogeneity of hemoglobin. IX. The use of Tris(hydroxymethyl)aminomethanehcl buffers in the anion-exchange chromatography of hemoglobins.

Authors:  T H Huisman; A M Dozy
Journal:  J Chromatogr       Date:  1965-07

8.  Localization of the human alpha-globin structural gene to chromosome 16 in somatic cell hybrids by molecular hybridization assay.

Authors:  A Deisseroth; A Nienhuis; P Turner; R Velez; W F Anderson; F Ruddle; J Lawrence; R Creagan; R Kucherlapati
Journal:  Cell       Date:  1977-09       Impact factor: 41.582

9.  Alpha-thalassaemia in Cuba.

Authors:  G Martinez; B Colombo
Journal:  Acta Haematol       Date:  1976       Impact factor: 2.195

10.  The beta-globin gene is on the short arm of human chromosome 11.

Authors:  L Sanders-Haigh; W F Anderson; U Francke
Journal:  Nature       Date:  1980-02-14       Impact factor: 49.962
  10 in total

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