Literature DB >> 11971956

Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.

Randy Shen1, Ying-Bin Ouyang, Cheng-Kui Qu, Andres Alonso, Lindsey Sperzel, Tomas Mustelin, Mark H Kaplan, Gen-Sheng Feng.   

Abstract

Grb-2-related adaptor protein (Grap) is a Grb2-like SH3-SH2-SH3 adaptor protein with expression restricted to lymphoid tissues. Grap(-/-) lymphocytes isolated from targeted Grap-deficient mice exhibited enhanced proliferation, interleukin-2 production, and c-fos induction in response to mitogenic T-cell receptor (TCR) stimulation, compared to wild-type cells. Ectopic expression of Grap led to a suppression of Elk-1-directed transcription induced by the Ras/Erk pathway, without having effects on gene expression mediated by Jnk and p38 mitogen-activated protein kinases. Together, these data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway.

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Year:  2002        PMID： 11971956      PMCID： PMC133801          DOI： 10.1128/MCB.22.10.3230-3236.2002

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  50 in total

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