Literature DB >> 20610546

The LAT story: a tale of cooperativity, coordination, and choreography.

Lakshmi Balagopalan1, Nathan P Coussens, Eilon Sherman, Lawrence E Samelson, Connie L Sommers.   

Abstract

The adapter molecule LAT is a nucleating site for multiprotein signaling complexes that are vital for the function and differentiation of T cells. Extensive investigation of LAT in multiple experimental systems has led to an integrated understanding of the formation, composition, regulation, dynamic movement, and function of LAT-nucleated signaling complexes. This review discusses interactions of signaling molecules that bind directly or indirectly to LAT and the role of cooperativity in stabilizing LAT-nucleated signaling complexes. In addition, it focuses on how imaging studies visualize signaling assemblies as signaling clusters and demonstrate their dynamic nature and cellular fate. Finally, this review explores the function of LAT based on the interpretation of mouse models using various LAT mutants.

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Year:  2010        PMID： 20610546      PMCID： PMC2908767          DOI： 10.1101/cshperspect.a005512

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  161 in total

Review 1.  Themes and variations on ubiquitylation.

Authors:  A M Weissman
Journal:  Nat Rev Mol Cell Biol       Date:  2001-03       Impact factor: 94.444

2.  The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells.

Authors:  I Tamir; J C Stolpa; C D Helgason; K Nakamura; P Bruhns; M Daeron; J C Cambier
Journal:  Immunity       Date:  2000-03       Impact factor: 31.745

3.  Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Authors:  S C Bunnell; M Diehn; M B Yaffe; P R Findell; L C Cantley; L J Berg
Journal:  J Biol Chem       Date:  2000-01-21       Impact factor: 5.157

4.  Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis.

Authors:  S I Gringhuis; A Leow; E A Papendrecht-Van Der Voort; P H Remans; F C Breedveld; C L Verweij
Journal:  J Immunol       Date:  2000-02-15       Impact factor: 5.422

5.  T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

Authors:  Rajat Varma; Gabriele Campi; Tadashi Yokosuka; Takashi Saito; Michael L Dustin
Journal:  Immunity       Date:  2006-07       Impact factor: 31.745

Review 6.  Negative signaling in Fc receptor complexes.

Authors:  Marc Daëron; Renaud Lesourne
Journal:  Adv Immunol       Date:  2006       Impact factor: 3.543

Review 7.  SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond.

Authors:  Gary A Koretzky; Farhad Abtahian; Michael A Silverman
Journal:  Nat Rev Immunol       Date:  2006-01       Impact factor: 53.106

8.  The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity.

Authors:  Céline Genton; Ying Wang; Shozo Izui; Bernard Malissen; Georges Delsol; Gilbert J Fournié; Marie Malissen; Hans Acha-Orbea
Journal:  J Immunol       Date:  2006-08-15       Impact factor: 5.422

9.  Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

Authors:  S C Bunnell; V Kapoor; R P Trible; W Zhang; L E Samelson
Journal:  Immunity       Date:  2001-03       Impact factor: 31.745

10.  Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.

Authors:  Matthias Hundt; Hiroki Tabata; Myung-Shin Jeon; Keitaro Hayashi; Yoshihiko Tanaka; Roma Krishna; Lauren De Giorgio; Yun-Cai Liu; Masaki Fukata; Amnon Altman
Journal:  Immunity       Date:  2006-05       Impact factor: 31.745
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  87 in total

Review 1.  Immunoreceptor signaling.

Authors:  Lawrence E Samelson
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-12-01       Impact factor: 10.005

Review 2.  The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Authors:  Lakshmi Balagopalan; Robert L Kortum; Nathan P Coussens; Valarie A Barr; Lawrence E Samelson
Journal:  J Biol Chem       Date:  2015-09-09       Impact factor: 5.157

3.  Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Authors:  Nathan P Coussens; Ryo Hayashi; Patrick H Brown; Lakshmi Balagopalan; Andrea Balbo; Itoro Akpan; Jon C D Houtman; Valarie A Barr; Peter Schuck; Ettore Appella; Lawrence E Samelson
Journal:  Mol Cell Biol       Date:  2013-08-26       Impact factor: 4.272

4.  La(s)t but not least.

Authors:  Bernard Malissen; Didier Marguet
Journal:  Nat Immunol       Date:  2011-06-20       Impact factor: 25.606

5.  Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.

Authors:  Lakshmi Balagopalan; Benjamin A Ashwell; Kelsie M Bernot; Itoro O Akpan; Naeha Quasba; Valarie A Barr; Lawrence E Samelson
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-31       Impact factor: 11.205

6.  Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation.

Authors:  Asit Manna; Huaying Zhao; Junya Wada; Lakshmi Balagopalan; Harichandra D Tagad; Ettore Appella; Peter Schuck; Lawrence E Samelson
Journal:  Proc Natl Acad Sci U S A       Date:  2018-12-03       Impact factor: 11.205

7.  Mechanisms determining a differential threshold for sensing Src family kinase activity by B and T cell antigen receptors.

Authors:  Simon Borna; Matej Fabisik; Kristyna Ilievova; Tomas Dvoracek; Tomas Brdicka
Journal:  J Biol Chem       Date:  2020-07-14       Impact factor: 5.157

8.  GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells.

Authors:  Mahmood Y Bilal; Elizabeth Y Zhang; Brittney Dinkel; Daimon Hardy; Thomas M Yankee; Jon C D Houtman
Journal:  Cell Signal       Date:  2015-01-28       Impact factor: 4.315

9.  Structure, function, and on-off switching of a core unit contact between CheA kinase and CheW adaptor protein in the bacterial chemosensory array: A disulfide mapping and mutagenesis study.

Authors:  Andrew M Natale; Jane L Duplantis; Kene N Piasta; Joseph J Falke
Journal:  Biochemistry       Date:  2013-10-22       Impact factor: 3.162

10.  Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.

Authors:  Lakshmi Balagopalan; Valarie A Barr; Robert L Kortum; Anna K Park; Lawrence E Samelson
Journal:  J Immunol       Date:  2013-03-13       Impact factor: 5.422
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