Literature DB >> 11968207

Kinetics of 5-enolpyruvylshikimate-3-phosphate synthase inhibition by glyphosate.

M R Boocock1, J R Coggins.   

Abstract

The herbicide glyphosate (N-phosphonomethyl glycine) is a potent reversible inhibitor of the 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase activity of the purified arom multienzyme complex from Neurospora crassa. Inhibition of the EPSP synthase reaction by glyphosate is competitive with respect to phosphoenolpyruvate, with K(i) 1.1 microM, and uncompetitive with respect to shikimate-3-phosphate. The kinetic patterns are consistent with a compulsory order sequential mechanism in which either PEP or glyphosate can bind to an enzyme: shikimate-3-phosphate complex.

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Year:  1983        PMID： 11968207     DOI： 10.1016/0014-5793(83)80888-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  45 in total

1.  Structure and topological symmetry of the glyphosate target 5-enolpyruvylshikimate-3-phosphate synthase: a distinctive protein fold.

Authors:  W C Stallings; S S Abdel-Meguid; L W Lim; H S Shieh; H E Dayringer; N K Leimgruber; R A Stegeman; K S Anderson; J A Sikorski; S R Padgette; G M Kishore
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

2.  The pentafunctional arom enzyme of Saccharomyces cerevisiae is a mosaic of monofunctional domains.

Authors:  K Duncan; R M Edwards; J R Coggins
Journal:  Biochem J       Date:  1987-09-01       Impact factor: 3.857

3.  5-enolpyruvylshikimate 3-phosphate synthase, the target enzyme of the herbicide glyphosate, is synthesized as a precursor in a higher plant.

Authors:  H Holländer-Czytko; N Amrhein
Journal:  Plant Physiol       Date:  1987-02       Impact factor: 8.340

4.  Purification and properties of 5-enolpyruvylshikimate 3-phosphate synthase from seedlings of Pisum sativum L.

Authors:  D M Mousdale; J R Coggins
Journal:  Planta       Date:  1984-01       Impact factor: 4.116

5.  Simultaneous substitution of Gly96 to Ala and Ala183 to Thr in 5-enolpyruvylshikimate-3-phosphate synthase gene of E. coli (k12) and transformation of rapeseed (Brassica napus L.) in order to make tolerance to glyphosate.

Authors:  Danial Kahrizi; Ali Hatef Salmanian; Afsoon Afshari; Ahmad Moieni; Amir Mousavi
Journal:  Plant Cell Rep       Date:  2006-07-28       Impact factor: 4.570

6.  Purification and properties of a glyphosate-tolerant 5-enolpyruvylshikimate 3-phosphate synthase from the cyanobacterium Anabaena variabilis.

Authors:  H A Powell; N W Kerby; P Rowell; D M Mousdale; J R Coggins
Journal:  Planta       Date:  1992-11       Impact factor: 4.116

7.  Novel AroA with high tolerance to glyphosate, encoded by a gene of Pseudomonas putida 4G-1 isolated from an extremely polluted environment in China.

Authors:  Yi-Cheng Sun; Yan-Cheng Chen; Zhe-Xian Tian; Feng-Mei Li; Xin-Yue Wang; Jing Zhang; Zhen-Long Xiao; Min Lin; Niamh Gilmartin; David N Dowling; Yi-Ping Wang
Journal:  Appl Environ Microbiol       Date:  2005-08       Impact factor: 4.792

8.  Reconstitution of glyphosate resistance from a split 5-enolpyruvyl shikimate-3-phosphate synthase gene in Escherichia coli and transgenic tobacco.

Authors:  Bao-Qing Dun; Xu-Jing Wang; Wei Lu; Zhong-Lin Zhao; Song-Na Hou; Bao-Ming Zhang; Gui-Ying Li; Thomas C Evans; Ming-Qun Xu; Min Lin
Journal:  Appl Environ Microbiol       Date:  2007-10-19       Impact factor: 4.792

9.  Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli.

Authors:  Todd Funke; Yan Yang; Huijong Han; Martha Healy-Fried; Sanne Olesen; Andreas Becker; Ernst Schönbrunn
Journal:  J Biol Chem       Date:  2009-02-11       Impact factor: 5.157

10.  Expression and stability of amplified genes encoding 5-enolpyruvylshikimate-3-phosphate synthase in glyphosate-tolerant tobacco cells.

Authors:  Y X Wang; J D Jones; S C Weller; P B Goldsbrough
Journal:  Plant Mol Biol       Date:  1991-12       Impact factor: 4.076
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