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Literature DB >> 11967169

Messenger RNA degradation: beginning at the end.

Abstract

The mechanisms responsible for mRNA decay in mammalian cells, and how specific sequence elements accelerate decay, are unknown. Recent work indicates that 'ARE' instability elements recruit the exosome to promote rapid 3'-to-5' degradation of the mRNA.

Entities: Gene Species

Mesh：

Substances：

Year: 2002 PMID： 11967169 DOI： 10.1016/s0960-9822(02)00802-3

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

31 in total

1. A role for the exosome in the in vivo degradation of unstable mRNAs.

Authors: Simon Haile; Antonio M Estevez; Christine Clayton
Journal: RNA Date: 2003-12 Impact factor: 4.942

2. DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.

Authors: Erwin van Dijk; Hervé Le Hir; Bertrand Séraphin
Journal: Proc Natl Acad Sci U S A Date: 2003-10-01 Impact factor: 11.205

3. Characterization of deadenylation in trypanosome extracts and its inhibition by poly(A)-binding protein Pab1p.

Authors: Joseph Milone; Jeffrey Wilusz; Vivian Bellofatto
Journal: RNA Date: 2004-03 Impact factor: 4.942

4. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.

Authors: Elena Tzouanacou; Susan Tweedie; Valerie Wilson
Journal: Mol Cell Biol Date: 2003-12 Impact factor: 4.272

5. RNA channelling by the archaeal exosome.

Authors: Esben Lorentzen; Andrzej Dziembowski; Doris Lindner; Bertrand Seraphin; Elena Conti
Journal: EMBO Rep Date: 2007-03-23 Impact factor: 8.807

6. Replication error deficient and proficient colorectal cancer gene expression differences caused by 3'UTR polyT sequence deletions.

Authors: Jennifer L Wilding; Simon McGowan; Ying Liu; Walter F Bodmer
Journal: Proc Natl Acad Sci U S A Date: 2010-11-19 Impact factor: 11.205

Messenger RNA degradation: beginning at the end.

1. A role for the exosome in the in vivo degradation of unstable mRNAs.

2. DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway.

3. Characterization of deadenylation in trypanosome extracts and its inhibition by poly(A)-binding protein Pab1p.

4. Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.

5. RNA channelling by the archaeal exosome.

6. Replication error deficient and proficient colorectal cancer gene expression differences caused by 3'UTR polyT sequence deletions.

7. New markers for old stains: stable mRNA markers for blood and saliva identification from up to 16-year-old stains.

8. Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.

9. The 'scavenger' m7GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast.

10. Forensic pregnancy diagnostics with placental mRNA markers.