Literature DB >> 11958988

Evaluation of morphogenic regulatory activity of farnesoic acid and its derivatives against Candida albicans dimorphism.

Sanghee Kim1, Eunkyung Kim, Dong Sun Shin, Heonjoong Kang, Ki Bong Oh.   

Abstract

A series of farnesoic acid derivatives was prepared and their morphogenic regulatory activities were evaluated. Their inhibitory activities against yeast cell growth and yeast-to-hypha transition examined in Candida albicans cells are dependent upon the chain length as well as the substitution patterns on the isoprenoid template. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements.

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Year:  2002        PMID: 11958988     DOI: 10.1016/s0960-894x(02)00038-0

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  12 in total

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